Sleep Spindles Predict Neural and Behavioral Changes in Motor Sequence Consolidation
Sleep Spindles Predict Neural and Behavioral Changes in Motor Sequence Consolidation
复制标题
DOI：
10.1002/hbm.22116
复制
发表时间：
2013-11-01
影响因子：
4.8
通讯作者：
Doyon, Julien
中科院分区：
文献类型：
--
作者：
Barakat, Marc;Carrier, Julie;Doyon, Julien
本研究的目的是探讨睡眠纺锤波在运动序列巩固中的预测功能。在10名年轻健康受试者中获得BOLD反应，这些受试者使用左手非惯用手进行明确已知的5项序列训练，在晚上9点执行相同任务时进行扫描，然后在睡眠12小时后进行重新测试和扫描，在此期间记录多导睡眠图测量。使用自动算法检测睡眠纺锤波并量化其特征（即密度、振幅和持续时间）。分析显示，成绩的提高与纺锤波振幅之间存在显著的正相关关系。此外，在几个运动相关区域观察到BOLD信号的显著增加，其中大部分位于右半球，特别是在右侧皮质纹状体系统。这种BOLD信号的增加也与几个衍生的纺锤波振幅呈正相关。综上所述，我们的研究结果表明，睡眠纺锤波预测了夜间运动序列巩固的神经和行为变化。脑科学学报（英文版），2013。(c) 2012 Wiley期刊有限公司
The purpose of this study was to investigate the predictive function of sleep spindles in motor sequence consolidation. BOLD responses were acquired in 10 young healthy subjects who were trained on an explicitly known 5-item sequence using their left nondominant hand, scanned at 9:00 pm while performing that same task and then were retested and scanned 12 h later after a night of sleep during which polysomnographic measures were recorded. An automatic algorithm was used to detect sleep spindles and to quantify their characteristics (i.e., density, amplitude, and duration). Analyses revealed significant positive correlations between gains in performance and the amplitude of spindles. Moreover, significant increases in BOLD signal were observed in several motor-related areas, most of which were localized in the right hemisphere, particularly in the right cortico-striatal system. Such increases in BOLD signal also correlated positively with the amplitude of spindles at several derivations. Taken together, our results show that sleep spindles predict neural and behavioral changes in overnight motor sequence consolidation. Hum Brain Mapp 34:2918-2928, 2013. (c) 2012 Wiley Periodicals, Inc.