Caudal hindbrain participation in the suppression of feeding by central and peripheral bombesin.
Caudal hindbrain participation in the suppression of feeding by central and peripheral bombesin.
复制标题
尾后脑参与中枢和外周铃蟾肽抑制摄食。
DOI：
10.1152/ajpregu.1993.264.6.r1229
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Ritter,RC
中科院分区：
文献类型：
--
作者：
Ladenheim,EE;Ritter,RC
我们先前已经证明，向大鼠第四脑室注入蛙皮素(BBS)可以抑制大鼠的摄食，剂量比侧脑室给药后所需剂量小10-1000倍。这些结果表明，中央管理的BBS作用于尾部后脑，以抑制食物摄取。为了研究尾侧后脑结构在第四脑室BBS诱导的摄食抑制中的作用，我们制作了损毁以下区域的损伤：1)最后区(AP)和2)孤束内侧核(NST)。此外，我们还研究了AP/NST在外周BBS给药后抑制食物摄入中的作用。我们的实验表明，损毁AP/NST可取消第四脑室BBS对食物摄取的抑制，并减弱外周BBS对食物摄取的抑制。局限于AP的损毁可减弱第四脑室BBS对食物摄取的抑制，但对外周给药BBS的食物摄取抑制没有影响。这些结果表明，NST可能是中枢和外周给药BBS抑制摄食的共同神经底物。
We have previously demonstrated that bombesin (BBS) infused into the fourth cerebral ventricle in rats suppressed feeding at doses 10-1,000 times less than those required after lateral ventricular administration. These results suggest that centrally administered BBS acts in the caudal hindbrain to suppress food intake. To investigate the participation of caudal hindbrain structures in fourth-ventricular BBS-induced suppression of feeding, we made lesions that destroyed the following: 1) area postrema (AP) and 2) and medial nucleus of the solitary tract (NST). Additionally, we examined the role of the AP/NST in the suppression of food intake after peripheral BBS administration. Our experiments revealed that lesions of the AP/NST abolished the suppression of food intake by fourth-ventricular BBS and attenuated the suppression of food intake by peripheral BBS. Lesions restricted to the AP attenuated the suppression of food intake by fourth-ventricular BBS but had no effect on suppression of intake by peripherally administered BBS. These results suggest that the NST may be a common neural substrate for the inhibition of food intake by both centrally and peripherally administered BBS.