Contribution of default mode network to game and delayed-response task performance: power and connectivity analyses of theta oscillation in the monkey
Contribution of default mode network to game and delayed-response task performance: power and connectivity analyses of theta oscillation in the monkey
复制标题
默认模式网络对游戏和延迟响应任务性能的贡献：猴子θ振荡的功率和连接分析
DOI：
10.1101/2023.03.19.533320
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Watanabe Masataka
中科院分区：
文献类型：
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作者：
Kodama Tohru;Kojima Takashi;Honda Yoshiko;Hosokawa Takayuki;Karashima Akihiro;Watanabe Masataka
神经影像学研究表明，默认模式网络（DMN）的存在，在休息时表现出更大的活动，以及执行网络（EN），在认知任务期间被激活。DMN和EN被认为具有竞争功能。然而，最近的研究表明，这两个网络在某些认知任务中表现出共激活。为了阐明DMN如何工作以及DMN如何与EN相互作用以进行认知控制，我们记录了猴子内侧前额叶（前部DMN：aDMN）、后扣带/楔前叶（后部DMN：pDMN）和外侧前额叶（EN）区域的EEG活动。作为认知任务，我们采用了猴子猴子竞争性视频游戏（GAME）和延迟反应（DR）任务。我们关注θ振荡是因为它在认知控制中的重要性。我们还使用格兰杰因果分析检验了三个网络区域之间的θ带连接，发现DMN和EN在两个任务中协同工作。在所有三个网络区域中，我们发现游戏任务相关，但没有DR任务相关，从休息水平增加θ功率，可能是因为更高的认知需求与游戏任务的性能。在这两项任务中，θ振荡所传递的信息流更多地指向aDMN，而不是来自aDMN。aDMN中与游戏任务相关的θ功率增加应该得到来自EN和pDMN的θ振荡所传达的更多信息流的支持。
Neuroimaging studies have demonstrated the presence of a default mode network (DMN) which shows greater activity during rest, and an executive network (EN) which is activated during cognitive tasks. DMN and EN are thought to have competing functions. However, recent studies reported that the two networks show coactivation during some cognitive tasks. To clarify how DMN works and how DMN interacts with EN for cognitive control, we recorded EEG activities in the medial prefrontal (anterior DMN: aDMN), posterior cingulate/precuneus (posterior DMN: pDMN), and lateral prefrontal (EN) areas in the monkey. As cognitive tasks, we employed a monkey-monkey competitive video game (GAME) and a delayed-response (DR) task. We focused on theta oscillation because of its importance in cognitive control. We also examined theta band connectivity among the three network areas using the Granger causality analysis.DMN and EN were found to work cooperatively in both tasks. In all the three network areas, we found GAME-task-related, but no DR-task-related, increase in theta power from the resting level, maybe because of the higher cognitive demand associated with the GAME task performance. The information flow conveyed by the theta oscillation was directed more to aDMN than from aDMN for both tasks. The GAME-task-related increase in theta power in aDMN is supposed to be supported by more information flow conveyed by the theta oscillation from EN and pDMN.