Absence of deleterious palladin mutations in patients with familial pancreatic cancer.
Absence of deleterious palladin mutations in patients with familial pancreatic cancer.
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DOI：
10.1158/1055-9965.epi-09-0056
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Goggins M
中科院分区：
文献类型：
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作者：
Klein AP;Borges M;Griffith M;Brune K;Hong SM;Omura N;Hruban RH;Goggins M
已有研究表明，palladin基因（PALLD）的种系突变导致胰腺癌的家族聚集性，但证据不足且存在争议。我们对48例家族性胰腺癌患者的PALLD编码区进行了测序。我们没有发现任何有害的突变，也没有发现任何证据表明PALLD突变是家族性胰腺癌的原因。
It has been reported that germline mutations in the palladin gene (PALLD) cause the familial aggregation of pancreatic cancer, but the evidence is weak and controversial. We sequenced the coding regions of PALLD in 48 individuals with familial pancreatic cancer. We did not find any deleterious mutations and find no evidence to implicate mutations in PALLD as a cause of familial pancreatic cancer.