What Shapes Pulse Amplitude of Intracranial Pressure?
What Shapes Pulse Amplitude of Intracranial Pressure?
复制标题
DOI：
10.1089/neu.2009.0951
复制
发表时间：
2010-02-01
影响因子：
4.2
通讯作者：
Czosnyka, Marek
中科院分区：
文献类型：
--
作者：
Carrera, Emmanuel;Kim, Dong-Joo;Czosnyka, Marek
颅内压（ICP）的脉动分量已被证明是正常压力脑积水（NPH）和创伤性脑损伤（TBI）结局的预测因子。实验研究表明，根据指数颅脊髓顺应性曲线，ICP的脉冲幅度（AMP（ICP））依赖于平均ICP（mICP）和脑动脉血容量的脉冲幅度（AMP（CaBV））。在这项研究中，我们比较了mICP和AMP（CaBV）对NPH（输注研究）和TBI（自发记录）患者AMP（ICP）的影响。我们回顾性分析了25例NPH和43例TBI患者，采用经颅多普勒连续监测颅内压和脑血流速度（CBFV）。从CBFV波形中提取AMP（CaBV）。使用多元回归模型的偏系数a、B和c确定mICP和AMP（CaBV）对AMP（ICP）的影响：AMP（ICP）-a* mICP+B* AMP（CaBV）+c。与TBI患者相比，NPH患者的AMP（ICP）更依赖于mICP（偏系数a-0.93 vs-0.03; p
The pulsatile component of intracranial pressure (ICP) has been shown to be a predictor of outcome in normal pressure hydrocephalus (NPH) and traumatic brain injury (TBI). Experimental studies have demonstrated that the pulse amplitude of ICP (AMP(ICP)) is dependent on the mean ICP (mICP), and on the pulse amplitude of the cerebral arterial blood volume (AMP(CaBV)), according to the exponential craniospinal compliance curve. In this study, we compared the influence of mICP and AMP(CaBV) on AMP(ICP) in patients with NPH (infusion study) and TBI (spontaneous recording). We retrospectively analyzed 25 NPH and 43 TBI patients with continuous monitoring of ICP and cerebral blood flow velocity (CBFV), as assessed with transcranial doppler. AMP(CaBV) was extracted from the CBFV waveform. The influence of mICP and AMP(CaBV) on AMP(ICP) were determined using partial coefficients a, b, and c of the multiple regression model: AMP(ICP)-a* mICP+b* AMP(CaBV)+c. AMP(ICP) was more dependent on mICP in NPH patients than in TBI patients (partial coefficient a-0.93 versus-0.03; p