dentification of Aldh 1 a , Cyp 26 and RAR orthologs in protostomes pushes back he retinoic acid genetic machinery in evolutionary time to the bilaterian ancestor
dentification of Aldh 1 a , Cyp 26 and RAR orthologs in protostomes pushes back he retinoic acid genetic machinery in evolutionary time to the bilaterian ancestor
复制标题
原口动物中Aldh 1 a 、 Cyp 26和RAR直向同源物的鉴定将进化时间中的视黄酸遗传机制推回到两侧对称动物祖先
DOI：
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Cristian Cañestrob
中科院分区：
文献类型：
--
作者：
icard Albalata;Cristian Cañestrob
在脊椎动物中，视黄酸（RA）是一种重要的形态发生信号，它控制胚胎发育以及成年个体的器官内稳态。RA的作用依赖于RA遗传机制的功能，该机制包括一个代谢模块和一个信号传导模块。代谢模块通过RA合成酶Aldh1a和RA降解酶Cyp26的联合作用来调节RA的时空分布。信号传导模块包括核激素受体家族RAR和RXR的成员，并控制RA靶基因的转录状态。RA信号传导主要在脊索动物中被描述，但最近在非脊索动物后口动物中发现RA遗传机制的成分，这改变了我们对这种形态发生信号进化起源的看法，挑战了先前将RA遗传机制的出现与脊索动物身体结构起源相关联的假设。为了阐明RA机制的进化起源，我们对13种非后口动物后生动物的基因组数据库中的Aldh1a、Cyp26和RAR直系同源物进行了广泛的调查。我们的结果首次表明在原口动物中存在Aldh1a、Cyp26和RAR，这意味着RA机制的组成部分可能是动物基因组中古老的成分，在两侧对称动物的最后共同祖先中就已存在。有趣的是，我们的数据还揭示在动物进化过程中RA工具包多次发生独立丢失，这可能与比较基因组学相关。
In vertebrates, retinoic acid (RA) is an important morphogenetic signal that controls embryonic development, as well as organ homeostasis in adults. RA action depends on the function of the RA-genetic machinery, which includes a metabolic module and a signaling module. The metabolic module regulates the spatiotemporal distribution of RA by the combined action of the RA-synthesizing Aldh1a enzymes, and the RA-degrading Cyp26 enzymes. The signaling module includes members of the nuclear hormone receptors family RAR and RXR, and controls the transcriptional state of RA-target genes. RA-signaling has been described primarily in chordates, but the recent finding of elements of the RA-genetic machinery in non-chordate deuterostomes has changed our perspective on the evolutionary origin of this morphogenetic signal, challenging previous assumptions that related the invention of the RA-genetic machinery rotostomes cdysozoans ophotrocozoans ldh etinaldehyde dehydrogenases ilaterian evolution with the origin of the chordate body plan. To illuminate the evolutionary origin of the RA machinery we have conducted an extensive survey of Aldh1a, Cyp26 and RAR orthologs in genomic databases of 13 nondeuterostome metazoans. Our results show for the first time the presence of Aldh1a, Cyp26 and RAR in protostomes, which implies that the components of the RA machinery may be ancient elements of animal genomes, already present in the last common ancestor of bilaterians. Interestingly, our data also reveal that independent losses of the RA toolkit have occurred multiple times during animal evolution, which r the p s h C c o a i a s omparative genomics may have been relevant fo
影响因子：
5.1
作者：
Duester, G;Mic, FA;Molotkov, A
通讯作者：
Molotkov, A
欧米茄-扇贝晶状体的水晶蛋白。
DOI：
10.1074/jbc.m005625200
发表时间：
2000
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Piatigorsky,J;Kozmik,Z;Horwitz,J;Ding,L;Carosa,E;RobisonJr,WG;Steinbach,PJ;Tamm,ER
通讯作者：
Tamm,ER
脊索动物进化过程中前后模式的起源和 Hox 基因调控。
DOI：
10.1098/rstb.2001.0918
发表时间：
2001
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Schilling,TF;Knight,RD
通讯作者：
Knight,RD