Motor neuron involvement in experimental lumbar nerve root compression - A light and electron microscopic study
Motor neuron involvement in experimental lumbar nerve root compression - A light and electron microscopic study
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DOI：
10.1097/01.brs.0000257559.84494.15
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发表时间：
2007-03-15
期刊：
影响因子：
3
通讯作者：
Baba, Hisatoshi
中科院分区：
文献类型：
--
作者：
Kobayashi, Shigeru;Uchida, Kenzo;Baba, Hisatoshi
研究设计。本研究的目的是使用体内模型研究机械神经根压迫引起的腰部运动神经元的变化。本研究旨在利用体内模型探讨机械神经根压迫引起的腰椎运动神经元的变化。 目的。在腰部运动神经元中确定了神经根受压引起的轴突血流紊乱的影响。背景数据摘要。在考虑无力机制时，不应忽视腰部运动神经元，因此了解神经根受压导致脊髓运动神经元发生形态和功能变化非常重要。然而，很少有研究关注腹根机械压迫导致的轴突流动紊乱、轴突反应、染色质和细胞死亡所引起的神经元内部变化。方法。在杂种狗中，第七腰神经根被压缩 1 周，或使用夹子压缩 3 周。通过光学和电子显微镜检查继发于轴突反应的运动神经元的形态变化。结果。光镜和电子显微镜显示，从压迫开始 1 周起，腰脊髓运动神经元出现中央色素溶解。 3周后，腹角可见部分神经元发生凋亡。结论。需要注意的是，腰椎间盘突出症或腰椎管狭窄导致神经根受压的患者，其功能障碍不仅限于受压部位的退变，还因轴突反应而延伸至腰脊髓内的运动神经元。因此，小腿无力的患者应充分了解这些症状在手术后不会立即消失。
Study Design. The aim of this study is to investigate changes in lumbar motor neurons induced by mechanical nerve root compression using an in vivo model. This study is to investigate the changes of lumbar motor neuron induced by mechanical nerve root compression using in vivo model.Objectives. The effect of axonal flow disturbance induced by nerve root compression was determined in lumbar motor neuron.Summary of Background Data. The lumbar motor neuron should not be overlooked when considering the mechanism of weakness, so it is important to understand the morphologic and functional changes that occur in motor neurons of the spinal cord as a result of nerve root compression. However, few studies have looked at changes of neurons within the caused by disturbance of axonal flow, the axon reaction, chromatolysis, and cell death as a result of mechanical compression of the ventral root.Methods. In mongrel dogs, the seventh lumbar nerve root was compressed for 1 week, or 3 weeks using a clip. Morphologic changes of the motor neurons secondary to the axon reaction were examined by light and electron microscopy.Results. Light and electron microscopy showed central chromatolysis of motor neurons in the lumbar cord from 1 week after the start of compression. After 3 weeks, some neurons undergoing apoptosis were seen in the ventral horn.Conclusion. It is important to be aware that, in patients with nerve root compression due to lumbar disc herniation or lumbar canal stenosis, dysfunction is not confined to degeneration at the site of compression but also extends to the motor neurons within the lumbar cord as a result of the axon reaction. Patients with weakness of lower leg should therefore be fully informed of the fact that these symptoms will not resolve immediately after surgery.