A better fluorescent protein for whole-body imaging
A better fluorescent protein for whole-body imaging
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DOI：
10.1016/j.tibtech.2007.10.006
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发表时间：
2008-01-01
影响因子：
17.3
通讯作者：
Hoffman, Robert M.
中科院分区：
文献类型：
--
作者：
Hoffman, Robert M.
荧光蛋白全身成像是一种强大的技术，在小动物中有许多应用。更亮的红移蛋白质可以使全身成像更敏感，因为它减少了组织的吸收和散射。一种名为Katushka的新蛋白质被分离出来。它是已知最亮的蛋白质，发射波长超过620 nm。这种新的蛋白质为活体动物的许多细胞和分子过程的非侵入性全身成像提供了可能。
Whole-body imaging with fluorescent proteins is a powerful technology with many applications in small animals. Brighter, red-shifted proteins can make whole-body imaging more sensitive owing to reduced absorption by tissues and less scatter. A new protein called Katushka has been isolated. It is the brightest known protein with emission at wavelengths longer than 620 nm. This new protein offers the potential for non-invasive whole-body imaging of numerous cellular and molecular processes in live animals.