Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis
Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis
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DOI：
10.1021/acsnano.0c00007
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发表时间：
2020-04-28
期刊：
影响因子：
17.1
通讯作者：
Hwang, Nathaniel S.
中科院分区：
文献类型：
--
作者：
An, Young-Hyeon;Lee, Joon;Hwang, Nathaniel S.
在此，我们开发了一种离子导入经皮给药系统，用于有效地传递电可移动药物纳米载体(DNS)。我们的系统由便携式一次性反向电渗析(红色)电池组成，通过离子交换为离子导入产生电能。此外，为了给红色驱动的离子电渗体系提供药物储存库，我们使用了聚吡咯掺杂的聚乙烯醇(PYP)组成的导电水凝胶。PYP水凝胶促进了红色电池的电子转移，并加速了从PYP水凝胶中释放的电可移动的DNS的迁移率。在本研究中，我们发现氟康唑或罗格列酮负载的丹参可以通过电荷诱导剂进行功能化，而荷电修饰的丹参通过排斥红色驱动的离子导入促进透皮吸收。此外，局部应用和红色驱动的离子导入导致罗格列酮负载的DNS在体内显示出有效的抗肥胖状态，表现为体重减轻，血糖水平降低，白色脂肪组织向棕色脂肪组织的转化增加。因此，我们强调，这一经皮给药平台将被广泛用于以非侵入性方式输送各种治疗药物。
We herein developed an iontophoretic transdermal drug delivery system for the effective delivery of electrically mobile drug nanocarriers (DNs). Our system consists of a portable and disposable reverse electrodialysis (RED) battery that generates electric power for iontophoresis through the ionic exchange. In addition, in order to provide a drug reservoir to the RED-driven iontophoretic system, an electroconductive hydrogel composed of polypyrrole-incorporated poly(vinyl alcohol) (PYP) was used. The PYP hydrogel facilitated electron transfer from the RED battery and accelerated the mobility of electrically mobile DNs released from the PYP hydrogel. In this study, we showed that fluconazole- or rosiglitazone-loaded DNs could be functionalized with charge-inducing agents, and DNs with charge modification resulted in facilitated transdermal transport via repulsive RED-driven iontophoresis. In addition, topical application and RED-driven iontophoresis of rosiglitazone-loaded DNs resulted in an effective antiobese condition displaying decreased bodyweight, reduced glucose level, and increased conversion of white adipose tissues to brown adipose tissues in vivo. Consequently, we highlight that this transdermal drug delivery platform would be extensively utilized for delivering diverse therapeutic agents in a noninvasive way.