Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation
Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation
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DOI：
10.1016/s0014-5793(03)01343-7
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发表时间：
2003-12-18
期刊：
影响因子：
3.5
通讯作者：
Schrauwen, P
中科院分区：
文献类型：
--
作者：
Hoeks, J;Hesselink, MKC;Schrauwen, P
我们比较了大鼠心肌、糖酵解和氧化骨骼肌中的UCP 3蛋白，并研究了高脂肪中链与长链甘油三酯喂养对这些组织中UCP 3含量的影响。心肌显示UCP 3蛋白的最低基础水平。增加长链-而不是中链-脂肪酸供应上调所有肌肉中的UCP 3。由于血浆非脂肪酸和两个过氧化物酶体增殖物激活受体（PPAR）反应基因的表达，组间没有差异，我们得出结论，UCP 3的差异上调不仅仅是PPAR介导的。这项研究支持UCP 3在输出不可代谢脂肪酸中的作用。(C)2003年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
We compared UCP3 protein in rat cardiac, glycolytic and oxidative skeletal muscle and examined the effect of high-fat medium chain vs. long chain triacylglycerol feeding on UCP3 content in these tissues. Cardiac muscle displays the lowest basal levels of UCP3 protein. Increasing long chain - but not medium chain - fatty acid supply upregulates UCP3 in all muscles. Since plasma non-esteritied fatty acids and the expression of two peroxisome proliferator-activated receptor (PPAR)responsive genes, were not different between groups, we conclude that the differential upregulation of UCP3 is not merely PPAR-mediated. This study supports a role of UCP3 in export of non-metabolizable fatty acids. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.