The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens
The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens
复制标题
结肠巨噬细胞转录因子 RBP-J 协调肠道针对细菌病原体的免疫
DOI：
10.1084/jem.20190762
复制
发表时间：
2020-04-01
影响因子：
15.3
通讯作者：
Hu, Xiaoyu
中科院分区：
文献类型：
--
作者：
Kang, Lan;Zhang, Xiang;Hu, Xiaoyu
肠道巨噬细胞中的转录因子RBP-J通过与T细胞和ILCs相互作用，动态调控抗菌免疫。巨噬细胞固有的RBP-J通过产生IL-6支持肠道Th17细胞的反应，而RBP-J缺陷意外地揭示了ILC3在感染后期的代偿作用。
Transcription factor RBP-J in intestinal macrophages dynamically controls antibacterial immunity by interfacing with T cells and ILCs. Macrophage-intrinsic RBP-J supports intestinal Th17 cell responses via IL-6 production, whereas RBP-J deficiency unexpectedly reveals a compensatory role for ILC3 late during infection.