Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma
Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma
复制标题
黄芍叶的甲醇和丁醇提取物抑制鳞状细胞癌的转移
DOI：
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发表时间：
2016
影响因子：
--
通讯作者：
T. Shirota
中科院分区：
文献类型：
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作者：
Y. Mukudai;Meilin Zhang;Sunao Shiogama;S. Kondo;C. Ito;Hiromi Motohashi;Kosuke Kato;Miharu Fujii;S. Shintani;H. Shigemori;K. Yazawa;T. Shirota
鳞状细胞癌（SCC）是世界范围内头颈部最常见的癌症之一，通常通过手术结合放疗和/或化疗进行治疗。然而，抗癌剂具有许多严重的副作用，并且需要作为SCC的化疗剂有效的替代的、毒性较小的药剂。芍药科植物广泛应用于中药中。我们研究了黄花海棠（P. lutea）叶的甲醇和丁醇提取物作为抗癌剂的潜力。这两种提取物降低了SCC细胞的增殖，诱导凋亡性细胞死亡，并调制迁移，粘附，趋化性和haptotaxis在细胞外基质（ECM）依赖性的方式，由于改变了几个整合素亚基的表达。随后，将SCC细胞皮下移植到无胸腺裸鼠中;提取物减少了SCC细胞的转移，但对原发肿瘤的体积或小鼠的存活率或体重几乎没有影响。结果表明，提取物可能有希望防止癌症转移。
Squamous cell carcinoma (SCC) is one of the most common cancers of the head and neck region worldwide and is generally treated surgically in combination with radiotherapy and/or chemotherapy. However, anticancer agents have numerous serious side effects, and alternative, less toxic agents that are effective as chemotherapeutics for SCC are required. The Paeoniaceae family is widely used in traditional Chinese medicine. We examined methanol and butanol extracts of Paeonia lutea (P. lutea) leaves for their potential as an anticancer agent. Both extracts decreased the proliferation of SCC cells, induced apoptotic cell death, and modulated migration, adhesion, chemotaxis, and haptotaxis in an extracellular matrix- (ECM-) dependent manner due to altered expression of several integrin subunits. Subsequently, SCC cells were subcutaneously transplanted into athymic nude mice; the extracts reduced the metastasis of SCC cells but had little effect on the volume of the primary tumor or survival or body weight of the mice. The results suggest that the extracts may hold promise for preventing cancer metastasis.
DOI：
10.1620/tjem.219.177
发表时间：
2009-11
期刊：
The Tohoku journal of experimental medicine
影响因子：
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作者：
Rybak LP;Mukherjea D;Jajoo S;Ramkumar V
通讯作者：
Ramkumar V