Efficient Synthesis of Sugar Oxazolines from Unprotected N-Acetyl-2-amino Sugars by Using Chloroformamidinium Reagent in Water
Efficient Synthesis of Sugar Oxazolines from Unprotected N-Acetyl-2-amino Sugars by Using Chloroformamidinium Reagent in Water
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DOI：
10.1021/jo8024708
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发表时间：
2009-03-06
影响因子：
3.6
通讯作者：
Shoda, Shin-ichiro
中科院分区：
文献类型：
--
作者：
Noguchi, Masato;Tanaka, Tomonari;Shoda, Shin-ichiro
在水介质中，利用氯甲脒型脱水剂，由相应的N-乙酰基-2-氨基糖直接合成了糖恶唑啉衍生物。本方法可成功地应用于壳寡糖、具有酸功能的寡糖和由糖肽衍生的复合型寡糖。
Sugar oxazoline derivatives were directly synthesized from the corresponding N-acetyl-2-amino sugars in aqueous media by using a chloroformamidinium-type dehydrating reagent. The present method could successfully be applied to chito-oligosaccharides, saccharides with acid functions, and a complex-type oligosaccharide derived from a glycopeptide.