Creating immune privilege: active local suppression that benefits friends, but protects foes
Creating immune privilege: active local suppression that benefits friends, but protects foes
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DOI：
10.1038/nri2233
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发表时间：
2008-01-01
影响因子：
100.3
通讯作者：
Munn, David H.
中科院分区：
文献类型：
--
作者：
Mellor, Andrew L.;Munn, David H.
自然调节机制防止不适当的免疫激活对自身和无害的外来抗原。在这里，我们调整了免疫特权的概念，最初应用于移植组织，考虑抗原肿瘤细胞和慢性病原体如何利用自然调节机制成为非免疫原性。这一概念方法揭示了新的机制观点，可能有助于解释肿瘤和慢性病原体的矛盾持久性，并为改善免疫疗法治疗这些慢性炎症性疾病提供了新的机会。
Natural regulatory mechanisms prevent inappropriate immune activation to self and innocuous foreign antigens. Here, we adapt the notion of immune privilege, which was originally applied to transplanted tissues, to consider how antigenic tumour cells and chronic pathogens might exploit natural regulatory mechanisms to become non-immunogenic. This conceptual approach reveals new mechanistic perspectives that may help to explain the paradoxical persistence of tumours and chronic pathogens, and suggests new opportunities to improve immunotherapy to treat these chronic inflammatory diseases.