The Ph1 Locus Suppresses Cdk2-Type Activity during Premeiosis and Meiosis in Wheat
The Ph1 Locus Suppresses Cdk2-Type Activity during Premeiosis and Meiosis in Wheat
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DOI：
10.1105/tpc.111.094771
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发表时间：
2012-01-01
期刊：
影响因子：
11.6
通讯作者：
Shaw, Peter
中科院分区：
文献类型：
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作者：
Greer, Emma;Martin, Azahara C.;Shaw, Peter
尽管拥有多组相关（同源）染色体，六倍体小麦（Triticum aestivum）在减数分裂时将配对限制为仅真正的同源染色体。删除单个主要基因座，配对同源 1 (Ph1)，允许同源配对。相同的染色体如何被处理为同源染色体而不是被视为非同源染色体？ Ph1 最近被定义为一组有缺陷的细胞周期蛋白依赖性激酶 (Cdk) 样基因，与哺乳动物 Cdk2 具有一定的相似性。我们推断该簇可能会抑制 Cdk2 型活性，从而影响复制和组蛋白 H1 磷酸化。我们的研究确实揭示了这种效应，表明 Cdk2 型磷酸化在决定减数分裂期间染色体特异性方面具有重要作用。
Despite possessing multiple sets of related (homoeologous) chromosomes, hexaploid wheat (Triticum aestivum) restricts pairing to just true homologs at meiosis. Deletion of a single major locus, Pairing homoeologous1 (Ph1), allows pairing of homoeologs. How can the same chromosomes be processed as homologs instead of being treated as nonhomologs? Ph1 was recently defined to a cluster of defective cyclin-dependent kinase (Cdk)-like genes showing some similarity to mammalian Cdk2. We reasoned that the cluster might suppress Cdk2-type activity and therefore affect replication and histone H1 phosphorylation. Our study does indeed reveal such effects, suggesting that Cdk2-type phosphorylation has a major role in determining chromosome specificity during meiosis.