N Methods for Implant Acceptance and Wound Healing: Material Selection and Implant Location Modulate Macrophage and Fibroblast Phenotypes
N Methods for Implant Acceptance and Wound Healing: Material Selection and Implant Location Modulate Macrophage and Fibroblast Phenotypes
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DOI：
10.1002/adhm.201600532
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发表时间：
2016-10-01
影响因子：
10
通讯作者：
Bratlie, Kaitlin M.
中科院分区：
文献类型：
--
作者：
Boddupalli, Anuraag;Zhu, Lida;Bratlie, Kaitlin M.
本文综述了用于诱导巨噬细胞和成纤维细胞表型变化的材料和方法。在此，我们简要概述了巨噬细胞和成纤维细胞表型的变化如何成为识别植入物接受性、伤口愈合有效性的关键生物标志物，并且对于评估涉及天然和合成材料组合的一些混合策略的再生能力也至关重要。已经广泛研究了宿主反应期间存在的不同类型的细胞，以评估对不同材料的反应，并且存在多种制造生物相容性基底的材料方法。我们讨论了天然和合成材料如何被用于设计肺，心脏，肝脏，皮肤和肌肉骨骼植入物的理想结果，以及某些特性，如刚度，表面形状和孔隙度如何在宿主反应的进展中发挥关键作用。几个制造策略进行了讨论，以控制浸润的巨噬细胞和成纤维细胞的表型：脱细胞的支架，表面涂层，植入物的形状和孔径除了生化信号通路，可以抑制或加速不利的主机响应。重要的是要考虑所有不同的设计原则和材料制造标准，以评估植入材料或再生治疗策略的选择。
This review focuses on materials and methods used to induce phenotypic changes in macrophages and fibroblasts. Herein, we give a brief overview on how changes in macrophages and fibroblasts phenotypes are critical biomarkers for identification of implant acceptance, wound healing effectiveness, and are also essential for evaluating the regenerative capabilities of some hybrid strategies that involve the combination of natural and synthetic materials. The different types of cells present during the host response have been extensively studied for evaluating the reaction to different materials and there are varied material approaches towards fabrication of biocompatible substrates. We discuss how natural and synthetic materials have been used to engineer desirable outcomes in lung, heart, liver, skin, and musculoskeletal implants, and how certain properties such as rigidity, surface shape, and porosity play key roles in the progression of the host response. Several fabrication strategies are discussed to control the phenotype of infiltrating macrophages and fibroblasts: decellularization of scaffolds, surface coatings, implant shape, and pore size apart from biochemical signaling pathways that can inhibit or accelerate unfavorable host responses. It is essential to factor all the different design principles and material fabrication criteria for evaluating the choice of implant materials or regenerative therapeutic strategies.