Expression of Osteopontin in oesophageal squamous cell carcinoma
Expression of Osteopontin in oesophageal squamous cell carcinoma
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DOI：
10.1038/sj.bjc.6603296
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发表时间：
2006-09-04
影响因子：
8.8
通讯作者：
Aikou, T.
中科院分区：
文献类型：
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作者：
Kita, Y.;Natsugoe, S.;Aikou, T.
骨桥蛋白是一种多功能的34 kDa的细胞外基质蛋白，具有细胞结合结构域。它涉及细胞粘附和细胞迁移，因此被认为影响肿瘤发生和/或转移。本研究旨在探讨骨桥蛋白在食管鳞癌中的表达及其临床意义。在本研究中，我们采用免疫组化方法研究了175例食管鳞癌原发肿瘤手术标本中骨桥蛋白表达与临床病理因素（包括预后）之间的关系。骨桥蛋白在175例患者中的表达率为48%。骨桥蛋白表达与淋巴结转移、淋巴结浸润和临床分期显著相关（P分别为0.0015、0.037和0.033）。骨桥蛋白表达阳性的肿瘤较骨桥蛋白阴性的肿瘤有更多的淋巴结转移、淋巴管浸润和晚期。骨桥蛋白表达阴性者5年生存率高于骨桥蛋白表达阳性者（P = 0.035）。然而，多因素分析显示骨桥蛋白表达不是独立的预后因素。骨桥蛋白在食管鳞癌的发生、发展过程中起重要作用，检测骨桥蛋白的表达有助于预测食管鳞癌的恶性程度。
Osteopontin is a multifunctional 34 kDa extracellular matrix protein with a cell-binding domain. It is involved cell adhesion and cell migration and is therefore considered to influence tumorigenesis and/or metastasis. The purpose of the present study was to evaluate the clinical significance of Osteopontin expression in oesophageal squamous cell carcinoma (ESCC). In the present study, we immunohistochemically investigated the relationship between Osteopontin expression and clinicopathological factors including prognosis in surgical specimens of primary tumours in 175 patients with ESCC. Osteopontin was expressed in 48% of 175 patients. Osteopontin expression was significantly correlated with lymph node metastasis, lymphatic invasion, and stage (P = 0.0015, 0.037 and 0.033, respectively). Tumours with expressing Osteopontin exhibited more lymph node metastasis, lymphatic invasion and advanced stage than the tumour with negative Osteopontin expression. Five-year survival rate was better in patients with negative Osteopontin expression than in those with positive Osteopontin expression (P = 0.035). However, multivariate analysis revealed that Osteopontin expression was not an independent prognostic factor. As our findings suggest that Osteopontin may play an important role in progress of ESCC, the evaluation of Osteopontin expression is useful for predicting the malignant properties of ESCC.