Statistical evaluation of the diagnostic accuracy of methods used to determine the progression of visual field defects in glaucoma
Statistical evaluation of the diagnostic accuracy of methods used to determine the progression of visual field defects in glaucoma
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DOI：
10.1016/j.ophtha.2004.06.025
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发表时间：
2004-11-01
期刊：
影响因子：
13.7
通讯作者：
Ohashi, Y
中科院分区：
文献类型：
--
作者：
Mayama, C;Araie, M;Ohashi, Y
目的：从判断青光眼视野损伤（VFD）进展的比率和特异性方面评价趋势型分析，并报告一种新方法。设计：对实际青光眼病例和计算机模拟的视野（VF）结果进行回顾性分析，并对VFD进展判断方法的性能进行受试者工作特征曲线分析。参与者：1名 对来自 4 所大学转诊实践的 105 名开角型青光眼 (OAG) 患者的 105 只眼睛和 355 名临床稳定的 OAG 患者的 355 只眼睛进行 VF 模拟。方法：对使用总偏差 (TD)、平均偏差 (MD)、扇区 VF 平均 TD 和高级青光眼干预研究 (AGIS) 中使用的原始评分进行回归分析的方法进行比较。对355只稳定的OAG眼在短时间内重复两次VF测试，并计算重测波动，包括每个测试点的方差和2个测试点之间的协方差，以通过计算机模拟稳定的青光眼VF系列。每种方法的敏感性以 105 个进展性 VF 系列计算，特异性以 10 000 个模拟稳定青光眼 VF 系列计算。主要指标：敏感性（判断进展的比率）、特异性和诊断能力。结果：在一个测试位置上使用 TD 斜率的方法显示敏感性为 0.848 至 1.000，特异性为 0.105 至 1000。 0.721，2 个相邻测试位置的敏感性为 0.848，特异性为 0.722。显着负 MD 斜率与 P
Objective: To evaluate trend-type analyses to judge the progression of visual field damage (VFD) of glaucoma in terms of ratios of making judgments of progression and specificity, and to report a new method.Design: Retrospective analysis of visual field (VF) results of actual glaucoma cases and those simulated by computer, and receiver operating characteristic curve analysis of performance of methods to judge the progression of VFD.Participants: One hundred five eyes of 105 open-angle glaucoma (OAG) patients with progressing VFD and 355 eyes of 355 clinically stable OAG patients for VF simulation from 4 university-based referral practices.Methods: Methods using regression analysis of total deviation (TD), mean deviation (MD), mean TD of a sectored VF, and original scoring used in the Advanced Glaucoma Intervention Study (AGIS) were compared. A VF test was repeated twice in a short period on the 355 stable OAG eyes, and test-retest fluctuation, including variance at each test point and covariance between 2 test points, was calculated to simulate stable glaucomatous VF series by computer. The sensitivity of each method was calculated with 105 progressing VF series, and specificity was calculated with 10 000 simulated stable glaucomatous VF series.Main Outcome Measures: Sensitivity (ratios of making judgments of progression), specificity, and diagnostic power.Results: The methods using the TD slope on one test location showed a sensitivity of 0.848 to 1.000, with a specificity of 0.105 to 0.721, and on 2 adjacent test locations showed a sensitivity of 0.848, with a specificity of 0.722. A significant negative MD slope with P