Assessment of vitamin K status of the newborn infant.
Assessment of vitamin K status of the newborn infant.
复制标题
新生儿维生素 K 状况的评估。
DOI：
10.1097/00005176-199304000-00001
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发表时间：
1993
影响因子：
2.9
通讯作者：
Suttie,JW
中科院分区：
文献类型：
--
作者：
vonKries,R;Greer,FR;Suttie,JW
本文回顾了我们目前的知识评估的维生素K的状态，在人类婴儿，其中的缺陷状态已被描述。维生素K依赖性凝血因子的功能评估以及维生素K1（叶绿醌）的定量测定的实验室措施进行了审查。此外，还讨论了测量异常凝血酶原（一种由维生素K缺乏诱导的蛋白质（PIVKA‐II））的四种不同方法及其在临床儿科中的应用。最后，简要描述了用于评估维生素K状态的其他方法，包括血清骨钙素，γ-羧基谷氨酸的尿排泄，以及在所谓的维生素K循环中叶绿醌再生所需的酶的缺乏。
This article reviews our current knowledge of the assessment of vitamin K status in the human infant, where a deficiency state has been described. Laboratory measures for the functional assessment of vitamin K‐dependent coagulation factors as well as the quantitative assay for vitamin K1(phylloquinone) are reviewed. In addition, four different methods of measuring abnormal prothrombin, a protein induced by vitamin K absence (PIVKA‐II), and its use in clinical pediatrics are discussed. Finally, additional methods are briefly described for assessing vitamin K status, including serum osteocalcin, urinary excretion of γ‐carboxyglutamic acid, and deficiencies of the enzymes necessary for the regeneration of phylloquinone in the so‐called vitamin K cycle.