LOSS OF BRAIN-STEM SEROTONIN-CONTAINING AND SUBSTANCE-P-CONTAINING NEURONS IN PARKINSONS-DISEASE
LOSS OF BRAIN-STEM SEROTONIN-CONTAINING AND SUBSTANCE-P-CONTAINING NEURONS IN PARKINSONS-DISEASE
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DOI：
10.1016/0006-8993(90)90733-r
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发表时间：
1990-02-26
期刊：
影响因子：
2.9
通讯作者：
GEFFEN, LB
中科院分区：
文献类型：
--
作者：
HALLIDAY, GM;BLUMBERGS, PC;GEFFEN, LB
利用死后的免疫组织化学分析，我们已经确定了几个不同的神经元细胞群的变性，在脑干的病人死于特发性帕金森氏病。我们报告的第一个化学鉴定损失的假定5-羟色胺神经元中缝核的脑桥和物质P-含有神经节前神经元迷走神经背核。这一证据与其他证据相一致，即原发性神经病理过程并不局限于单一通路或含有特定递质的神经元。相反，帕金森病似乎影响脑干局部区域的几类神经元。
Using postmortem immunohistochemical analysis, we have identified degeneration of several different neuronal cell grops in the brainstem of patients dying with idiopathic Parkinson''s disease. We report the first chemically identified loss of presumed serotonin neurons in the median raphe nucleus of the pons and of substance P-containing preganglionic neurons in the dorsal motor vagal nucleus. This evidence is concordant with other evidence that the primary neuropathological process is not confined either to a single pathway or to neurons containing a particular transmitter. Rather it appears that Parkinson''s disease affects several classes of neurons in localized areas of the brainstem.