Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein
Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein
复制标题
DOI：
10.1006/bbrc.1997.8019
复制
发表时间：
1998-01-26
影响因子：
3.1
通讯作者：
Nabeshima, Y
中科院分区：
文献类型：
--
作者：
Matsumura, Y;Aizawa, H;Nabeshima, Y
小鼠klotho（kl）基因的失活会导致多种类似人类衰老的疾病。小鼠hi基因编码一种与β-葡糖苷酶具有同源性的新型单程膜蛋白。在这项研究中，我们已经分离出人类同源的kl基因，并确定其基因结构。人类kl基因由5个外显子组成，位于染色体13 q12上，长度超过50 kb。我们已经进一步确定了编码膜或分泌蛋白的两个转录本。这些转录物通过选择性RNA剪接由单个kl基因产生。假定的分泌形式的表达优于膜形式。本研究为进一步分析人类kl基因及其功能提供了必要的基础信息。(C)北京：科学出版社.
Inactivation of the klotho (kl) gene in mice results in multiple disorders that resemble human aging. The mouse hi gene encodes a novel single-pass membrane protein with homology to beta-glucosidases. In this study, we have isolated a human homologue of the kl gene and determined its gene structure. The human kl gene is composed of 5 exons and ranges over 50 kb on chromosome 13q12. We have further identified two transcripts that encode a membrane or secreted protein. These transcripts arise from a single kl gene through alternative RNA splicing. Expression of the putative secreted form predominates over that of the membrane form. The present study provides fundamental information necessary for further analyses of the human kl gene and its functions. (C) 1998 Academic Press.