Microbial synthetic biology
Microbial synthetic biology
复制标题
微生物合成生物学
DOI：
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
A. Wipat
中科院分区：
文献类型：
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作者：
C. Harwood;A. Wipat
微生物学方法第40卷侧重于微生物合成生物学。合成生物学是一门快速发展的学科，它建立在基因工程和生物技术的成熟原理基础上，通过将计算和工程方法整合到新生物系统的设计和构建中。本卷解决了一些主要的技术挑战，阻碍了我们在设计复杂的多尺度生物系统方面的能力的根本性转变。其中包括：计算智能在合成微生物系统设计中的应用，设计自动化和约束;噪声和随机性的影响;生物传感器的工程;模型细菌底盘的特性。合成生物学中的一个关键问题是它的社会维度，并且有一章专门讨论这个重要问题。产品特点：贡献者的权威或专业知识;微生物和微生物代谢设计和建模网站链接;解决实际问题的第一卷;以及关于负责任创新的讨论。
The 40th volume of Methods in Microbiology focuses on microbial synthetic biology. Synthetic biology is a rapidly growing discipline that builds on well-established principles of genetic engineering and biotechnology by integrating computational and engineering approaches to the design and construction of novel biological systems. This volume addresses some of the major technical challenges stand in the way of achieving a radical step-change in our ability to engineer complex multi-scaled biological systems. These include: the application of computation intelligence to the design of synthetic microbial systems, design automation and constraints; the impact of noise and stochasticity; the engineering of biosensors; the characteristic of a model bacterial chassis. A key issue in Synthetic Biology is that of its social dimensions and a chapter is dedicated to the important issue. Features: authority or expertise of contributors; links to websites for the design and modelling of microbes and microbial metabolism; first volume to address the practical issues; and discussion on responsible innovation.