It takes three to tango: genes complicate the association between birth weight and cardiovascular disease.
It takes three to tango: genes complicate the association between birth weight and cardiovascular disease.
复制标题
探戈需要三个步骤：基因使出生体重与心血管疾病之间的关联变得复杂。
DOI：
10.1161/circulationaha.111.037432
复制
发表时间：
2011
期刊：
影响因子：
37.8
通讯作者：
Palinski,Wulf
中科院分区：
文献类型：
--
作者：
Palinski,Wulf
心血管疾病（CVD）的危险因素被认为是众所周知的，但先天与后天的相对重要性仍在争论中。虽然性别、家族史和遗传易感性被认为是主要因素，但大多数注意力都集中在生活方式风险因素上，因为通过预防或治疗高胆固醇血症、糖尿病、高血压、肥胖和吸烟，可以获得实质性的临床益处。除了遗传因素和出生后的风险因素外，在过去的20年里，发育规划已成为心血管疾病的潜在决定因素。成人心血管疾病受子宫内胎儿发育条件的影响，这一概念主要源于Barker及其同事的观察，即低出生体重与心血管疾病的增加有关。这引发了一系列流行病学研究，其中大多数支持出生体重与心血管疾病和高血压的关联，而与2型糖尿病的关联仍有争议。4-6后来的研究强调需要区分早产导致的低出生体重和真正的宫内生长受限，并确定CVD风险实际上与根据妊娠期调整的出生体重有关。7
The risk factors of cardiovascular disease (CVD) are thought to be well known, but the relative importance of nature versus nurture continues to be debated. Although sex, family history, and genetic susceptibility are recognized as playing a major role, most attention has focused on lifestyle risk factors because of the substantial clinical benefits achievable—and achieved—by preventing or treating hypercholesterolemia, diabetes mellitus, hypertension, obesity, and smoking. In addition to genetically determined and postnatal risk factors, during the past 2 decades, developmental programming has emerged as a potential determinant of CVD. The concept that adult CVD is influenced by the conditions encountered by the developing fetus in utero originated largely from the observation by Barker and colleagues1 that low birth weight was associated with increased CVD. This prompted a flurry of epidemiological studies, the majority of which supported the association of birth weight with CVD and hypertension, 2, 3 whereas the association with type 2 diabetes mellitus remains more controversial. 4–6 Later studies highlighted the need to differentiate low birth weight resulting from premature birth from true intrauterine growth restriction and established that the CVD risk is in fact associated with birth weight adjusted for gestational length. 7