IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis
IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis
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DOI：
10.1016/j.clim.2005.01.011
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发表时间：
2005-05-01
影响因子：
8.6
通讯作者：
Metcalfe, DD
中科院分区：
文献类型：
--
作者：
Brockow, K;Akin, C;Metcalfe, DD
肥大细胞增多症通常与器官受累和血液系统疾病有关。患者还可能表现出血浆IL-6水平升高。为了深入了解这一观察结果的相关性，我们将29例肥大细胞增多症患者的血浆IL-6和可溶性IL-6受体(sIL-6R)水平与多种疾病参数相关联。与健康对照组相比，患者平均血浆IL-6水平升高(P<；0.0001)。疾病类别与血浆IL-6水平显著相关，骨髓病理严重程度、器官肿大和皮肤受累程度也是如此。血浆IL-6与总类胰酶、碱性磷酸酶、IgM、白细胞计数、凝血酶原时间、部分凝血活酶时间、中性粒细胞数呈正相关。与血红蛋白呈负相关。SIL-6R水平未见升高。这些观察表明，IL-6是一种有用的血液疾病严重程度的替代标记物，并提示IL-6在病理中起作用。由爱思唯尔公司出版。
Mastocytosis is often associated with organ involvement and hematological disorders. Patients may also exhibit elevated levels of plasma IL-6. To gain insight into the relevance of this observation, we correlated plasma levels of IL-6 and soluble IL-6 receptor (sIL-6R) with Multiple disease parameters in 29 patients with mastocytosis. Mean plasma IL-6 levels were elevated in patients compared to healthy controls (P < 0.0001). Disease category significantly correlated with plasma IL-6 levels, as did severity of bone marrow pathology, organomegaly, and extent of skin involvement. In plasma, there was a positive correlation of IL-6 to total tryptase, alkaline phosphatase, IgM, white blood cell count, prothrombin time, partial thromboplastin time, and neutrophil numbers. There was an inverse correlation to hemoglobin. sIL-6R levels were not elevated. These observations demonstrate that IL-6 is a useful surrogate marker of severity of hematologic disease and suggest that IL-6 contributes to pathology. Published by Elsevier Inc.