Altered Quality of Life and Psychological Health (SCL-90-R) in Patients With Chronic Rhinosinusitis With Nasal Polyps
Altered Quality of Life and Psychological Health (SCL-90-R) in Patients With Chronic Rhinosinusitis With Nasal Polyps
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DOI：
10.1177/0003489415576181
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发表时间：
2015-08-01
影响因子：
1.4
通讯作者：
Cho, Seok Hyun
中科院分区：
文献类型：
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作者：
Chung, Jae Ho;Lee, Yun Jae;Cho, Seok Hyun
目的：目的探讨嗅觉障碍对慢性鼻窦炎伴鼻息肉（CRSwNP）患者生活质量和心理状况的影响。所有患者均接受计算机断层扫描（CT）、过敏试验和嗅棒嗅觉试验。嗅觉缺失症的定义是指患者的鉴别力（TDI）评分小于16。结果：CRSwNP组的气味辨别和识别评分显著低于SD组（P = 0.008和P = 0.005）。在CRSwNP中，识别评分随着CT评分的升高而降低（r =-0.29，P = 0.014）。CRSwNP伴嗅觉丧失者生活质量下降（P = 0.044），重度CRSwNP患者SNOT-20与TDI呈负相关（CT评分15，r =-0.714，P = 0.001）。嗅觉缺失患者SCL-90-R的焦虑、恐怖因子分在SD和CRSwNP上均高于正常对照组。结论：嗅觉障碍可能对患者的生活质量和心理健康有显著影响。CRSwNP伴嗅觉丧失是一种独特的表型，具有混合型嗅觉丧失，可能对抑郁症产生不利影响。
Objectives: To investigate the impact of olfactory dysfunction on quality of life (QOL) and psychological status in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).Methods: A retrospective observational study was conducted from January 2011 to May 2012 with 130 patients with septal deviation (SD) (n = 59) and CRSwNP (n = 71). All patients underwent computed tomography (CT), allergy tests, and sniffin' stick olfactory test. Anosmia was defined by Threshold-Discrimination-Identification (TDI) scores less than 16. QOL and psychological symptoms were assessed with the Sinonasal Outcome Test-20 (SNOT-20) and Symptom Checklist-90-Revised (SCL-90-R).Results: Odor discrimination and identification scores were significantly lower in CRSwNP than in SD (P = .008 and P = .005, respectively). In CRSwNP, identification score decreased with higher CT score (r = -0.29, P = .014). CRSwNP with anosmia showed a decreased QOL (P = .044), and SNOT-20 negatively correlated with TDI in severe CRSwNP (CT score 15, r = -0.714, P = .001). Anosmia patients had higher anxiety and phobia scores of SCL-90-R in both SD and CRSwNP. However, depression score increased only in CRSwNP with anosmia (P = .025).Conclusion: Olfactory dysfunction may have significant effects on QOL and psychological health. CRSwNP with anosmia is a distinct phenotype having mixed type of olfactory loss that might have a detrimental effect on depression.