Role of glucagon in metabolic acclimation to cold and heat.
Role of glucagon in metabolic acclimation to cold and heat.
复制标题
胰高血糖素在冷热代谢适应中的作用。
DOI：
10.1016/0024-3205(78)90401-0
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
T. Ohno
中科院分区：
文献类型：
--
作者：
A. Kuroshima;K. Doi;T. Ohno
冷驯化2周后血浆胰高血糖素浓度升高，冷驯化4周后血浆胰高血糖素浓度恢复正常。血浆游离脂肪酸（FFA）和β-羟基丁酸浓度也表现出类似的变化模式。2周和4周热驯化动物血浆胰高血糖素和FFA浓度均下降。热驯化对血浆β-羟基丁酸盐浓度无明显影响。热驯化动物血浆葡萄糖浓度下降，而冷驯化动物血浆葡萄糖浓度不受影响。2周温、冷、热驯化大鼠和4周温、热驯化大鼠血浆胰高血糖素与游离脂肪酸整体水平呈显著正相关。这些发现似乎表明，在冷驯化和热驯化中，胰高血糖素作为激素团队的一员，通过调节脂质和碳水化合物代谢而密切参与。
Plasma glucagon concentration increased in 2 weeks cold-acclimated rats, but it returned to normal value in 4 weeks cold-acclimated ones. Plasma free fatty acid (FFA) and β-hydroxybutyrate concentrations also showed the similar pattern of changes. Plasma glucagon and FFA concentrations decreased in both 2 weeks and 4 weeks heat-acclimated animals. Plasma β-hydroxybutyrate concentration was not changed by heat acclimation. Plasma glucose concentration decreased in heat-acclimated animals, while it was not affected by cold acclimation. There was a significant positive correlation between plasma glucagon and FFA levels as a whole in 2 weeks warm-, cold- and heat-acclimated rats, and in 4 weeks warm- and heat-acclimated ones. These findings would appear to indicate that in both cold and heat acclimation glucagon is closely involved as one member of a hormonal team through regulating lipid and carbohydrate metabolism.