Progress in Understanding the IL-6/STAT3 Pathway in Colorectal Cancer.
Progress in Understanding the IL-6/STAT3 Pathway in Colorectal Cancer.
复制标题
结直肠癌中IL-6/STAT3通路的研究进展
DOI：
10.2147/ott.s278013
复制
发表时间：
2020
影响因子：
4
通讯作者：
Liang R
中科院分区：
文献类型：
--
作者：
Lin Y;He Z;Ye J;Liu Z;She X;Gao X;Liang R
白细胞介素-6（IL-6）作为一种多效性细胞因子，不仅调节细胞免疫应答，而且通过激活多种致癌途径促进肿瘤的发生发展。IL-6在结直肠癌（CRC）中的表达显著升高，并且与CRC的发展和患者预后密切相关。在CRC中，IL-6激活信号转导子和转导激活子3（STAT 3）以促进肿瘤起始和肿瘤生长。IL-6/STAT 3信号传导对CRC中肿瘤免疫微环境中的肿瘤浸润免疫细胞具有深远影响。此外，IL-6/STAT 3通路激活下游靶基因以保护肿瘤细胞免于凋亡;驱动肿瘤细胞增殖、细胞周期进展、侵袭和转移;促进肿瘤血管生成;并刺激耐药性。因此，需要彻底了解IL-6/STAT 3通路在CRC中的许多作用，本综述对此进行了研究。
As a pleiotropic cytokine, interleukin-6 (IL-6) not only regulates the cellular immune response, but it also promotes tumor development by activating multiple carcinogenic pathways. IL-6 expression is significantly elevated in colorectal cancer (CRC) and is closely related to CRC development and patient prognosis. In CRC, IL-6 activates signal transducers and activators of transduction-3 (STAT3) to promote tumor initiation and tumor growth. IL-6/STAT3 signalling has a profound effect on tumor-infiltrating immune cells in the tumor immune microenvironment in CRC. Additionally, IL-6/STAT3 pathway activates downstream target genes to protect tumor cells from apoptosis; drive tumor cell proliferation, cell cycle progression, invasion and metastasis; promote tumor angiogenesis; and stimulate drug resistance. Therefore, a thorough understanding of the many effects of the IL-6/STAT3 pathway in CRC is needed, which the present review examines.