Role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancer.
Role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancer.
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DOI：
10.1099/jgv.0.000320
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Yaqiong Wang;Kimberly Schmitt;K. Guo;M. Santiago;E. Stephens
中科院分区：
文献类型：
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作者：
Yaqiong Wang;Kimberly Schmitt;K. Guo;M. Santiago;E. Stephens
载脂蛋白基因编码酶催化多肽样3(APOBEC3；A3)蛋白是一个由7种胞苷脱氨酶(A3A、A3B、A3C、A3D、A3F、A3G和A3H)组成的家族，可限制某些病毒的感染。这些先天防御因子最为人所知的是它们能够限制缺乏功能Vif蛋白的人类免疫缺陷病毒1型(HIV-1ΔVif)的复制，方法是在逆转录过程中将胞苷残基脱氨为尿氨酸，最终导致病毒基因组中致命性的G→A变化。A3蛋白被研究得最好的是APOBEC3G，因为它对HIV-1ΔVIF具有很强的活性。然而，这个家族的一个成员，A3A，具有使其在A3蛋白中独一无二的生物学特性。在这篇综述中，我们将重点介绍人类和非人灵长类A3A蛋白的结构和系统发育特征，它们在限制逆转录病毒和其他病毒中的作用，以及受该蛋白影响的其他生物学特性的最新发现。
The apolipoprotein mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3; A3) proteins are a family of seven cytidine deaminases (A3A, A3B, A3C, A3D, A3F, A3G and A3H) that restrict certain viral infections. These innate defence factors are best known for their ability to restrict the replication of human immunodeficiency virus type 1 (HIV-1) lacking a functional Vif protein (HIV-1Δvif) through the deamination of cytidine residues to uridines during reverse transcription, ultimately leading to lethal G → A changes in the viral genome. The best studied of the A3 proteins has been APOBEC3G because of its potent activity against HIV-1Δvif. However, one member of this family, A3A, has biological properties that make it unique among the A3 proteins. In this review, we will focus on the structural and phylogenetic features of the human and non-human primate A3A proteins, their role in the restriction of retroviruses and other viruses, and current findings on other biological properties affected by this protein.