Who benefits from an eHealth-based stress management intervention in advanced prostate cancer? Results from a randomized controlled trial.
Who benefits from an eHealth-based stress management intervention in advanced prostate cancer? Results from a randomized controlled trial.
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DOI：
10.1002/pon.6000
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发表时间：
2022-12
期刊：
影响因子：
3.6
通讯作者：
Penedo, Frank J.
中科院分区：
文献类型：
--
作者：
Benzo, Roberto M.;Moreno, Patricia, I;Noriega-Esquives, Blanca;Otto, Amy K.;Penedo, Frank J.
关键词：
进行二次分析，以检查片剂递送、基于群体的认知-行为应激管理(CBSM)干预对减轻晚期前列腺癌(APC)患者症状负担的效果，并提高症状负担的基线水平。共有192名患有APC的男性被随机分为CBSM组或健康促进组，并进行了为期一年的跟踪调查。我们的研究包括六个分析样本，每个样本都包括报告基线时相应结果的负担水平升高的参与者。结果包括5个症状相关生活质量领域(尿失禁98例，尿路刺激61例，肠功能43例，性功能177例，激素功能149例)和抑郁(31例)。重复测量混合模型被用来检测组内和组间结果的变化。无论情况如何，症状负担升高或轻度到重度抑郁的参与者在尿路刺激、肠道功能、激素功能和抑郁评分方面显示出短期(6个月)的改善。只有在CBSM条件下的参与者表现出短期(6个月)尿失禁的改善，以及长期(12个月)的尿刺激、肠道功能、激素功能和抑郁评分的改善。我们的发现表明，针对最有可能受益的接受者(症状负担水平升高)的基于网络的CBSM干预可以改善APC男性患者与症状相关的生活质量和抑郁症状的多个领域。
Conduct a secondary analysis to examine the effects of a tablet-delivered, group-based cognitive-behavioral stress management (CBSM) intervention for reducing symptom burden among men with advanced prostate cancer (APC) and elevated baseline levels of symptom burden. A total of 192 men with APC were randomized to either a CBSM or a health promotion condition and followed for one year. Six analytical samples were included in our study, each including participants who reported elevated levels of burden for the corresponding outcome at baseline. Outcomes included five domains of symptom-related quality of life (urinary incontinence n = 98; urinary irritation n = 61; bowel function n = 43; sexual function n = 177; and hormonal function n = 149) and depression (n = 31). Repeated measures mixed models were used to detect within- and between-group changes in outcomes. Regardless of condition, participants with elevated symptom burden or mild-to-severe depression showed short-term (6-month) improvements in urinary irritation, bowel function, hormonal function, and depression scores. Only participants in the CBSM condition showed short-term (6-month) improvements in urinary incontinence, and long-term (12-month) improvements in urinary irritation, bowel function, hormonal function, and depression scores. Our findings suggest that targeting a web-based CBSM intervention to recipients most likely to benefit (elevated levels of symptom burden) can improve several domains of symptom-related quality of life and depressive symptoms in men with APC.
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影响因子：
3.1
作者：
Schneider, Stefan;Moyer, Anne;Knapp-Oliver, Sarah;Sohl, Stephanie;Cannella, Dolores;Targhetta, Valerie
通讯作者：
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影响因子：
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通讯作者：
Unwin, Jennifer
影响因子：
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作者：
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通讯作者：
Rashidi, Parisa