The Relationship between Maternal Plasma Leptin and Adiponectin Concentrations and Newborn Adiposity.
The Relationship between Maternal Plasma Leptin and Adiponectin Concentrations and Newborn Adiposity.
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DOI：
10.3390/nu9030182
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发表时间：
2017-02-23
期刊：
影响因子：
5.9
通讯作者：
Rondó PH
中科院分区：
文献类型：
--
作者：
Castro NP;Euclydes VV;Simões FA;Vaz-de-Lima LR;De Brito CA;Luzia LA;Devakumar D;Rondó PH
母亲血液中瘦素浓度升高和脂联素水平降低是肥胖的常见障碍，可能通过编程胎儿脂肪组织发育参与后代肥胖。本研究的目的是评估母亲瘦素和脂联素浓度与新生儿肥胖之间的关系。这是一项横断面研究，涉及来自巴西圣保罗一家公立妇产医院的210对健康的母亲和新生儿。分娩后采集产妇血样，采用酶联免疫吸附法测定瘦素和脂联素浓度。新生儿的身体成分通过空气置换脉搏描记仪估计。通过多元线性回归评估母亲瘦素和脂联素浓度与新生儿肥胖（脂肪质量百分比，FM%）之间的关系，控制母亲年龄、社会经济地位、胎次、孕前体重指数（BMI）、体重增加、胎龄和测量时的新生儿年龄。母亲瘦素与男性和女性新生儿的FM%没有关系。母体脂联素（p = 0.001）和孕前BMI （p < 0.001; adj. R2 = 0.19）与新生儿男性FM%呈正相关，提示母体脂联素以性别特异性的方式参与胎儿脂肪沉积。需要大规模的流行病学、纵向研究来证实我们的结果。
Increased maternal blood concentrations of leptin and decreased adiponectin levels, which are common disturbances in obesity, may be involved in offspring adiposity by programming fetal adipose tissue development. The aim of this study was to assess the relationship between maternal leptin and adiponectin concentrations and newborn adiposity. This was a cross-sectional study involving 210 healthy mother-newborn pairs from a public maternity hospital in São Paulo, Brazil. Maternal blood samples were collected after delivery and leptin and adiponectin concentrations were measured by enzyme-linked immunosorbent assay. Newborn body composition was estimated by air displacement plethysmography. The association between maternal leptin and adiponectin concentrations and newborn adiposity (fat mass percentage, FM%) was evaluated by multiple linear regression, controlling for maternal age, socioeconomic status, parity, pre-pregnancy body mass index (BMI), weight gain, gestational age, and newborn age at the time of measurement. No relationship was found between maternal leptin and FM% of male or female newborn infants. Maternal adiponectin (p = 0.001) and pre-pregnancy BMI (p < 0.001; adj. R2 = 0.19) were positively associated with FM% of newborn males, indicating that maternal adiponectin is involved in fetal fat deposition in a sex-specific manner. Large-scale epidemiological, longitudinal studies are necessary to confirm our results.