IBOTENIC ACID LESIONS IN THE BED NUCLEUS OF THE STRIA TERMINALIS ATTENUATE CONDITIONED STRESS-INDUCED INCREASES IN PROLACTIN, ACTH AND CORTICOSTERONE
IBOTENIC ACID LESIONS IN THE BED NUCLEUS OF THE STRIA TERMINALIS ATTENUATE CONDITIONED STRESS-INDUCED INCREASES IN PROLACTIN, ACTH AND CORTICOSTERONE
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DOI：
10.1159/000126400
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发表时间：
1993-03-01
影响因子：
4.1
通讯作者：
VANDEKAR, LD
中科院分区：
文献类型：
--
作者：
GRAY, TS;PIECHOWSKI, RA;VANDEKAR, LD
评估了终纹床核 (BST) 对应激诱导的 ACTH/皮质酮、催乳素和肾素分泌增加表达的贡献。通过双侧注射细胞选择性神经毒素鹅膏蕈酸（每侧 1.5 杯 0.1 微升溶液）破坏 BST 外侧部分的神经元。两周后，使用固定或条件应激模式对大鼠进行应激。 BST 外侧病变的大鼠表现出 ACTH 和皮质酮对条件应激的反应减弱。外侧 BST 的双侧消融显着降低了催乳素分泌对条件应激的反应。相同的损伤对响应条件应激而发生的血浆肾素增加没有影响。此外，BST 中神经元的破坏不会影响固定诱导的 ACTH、皮质酮、催乳素或肾素的增加。先前的研究表明，杏仁核中央的鹅膏蕈酸损伤会降低皮质酮和肾素对条件应激的反应。因此，BST 和中央杏仁核对于肾上腺皮质对条件应激的反应都很重要。杏仁核中央核中的神经元是介导肾素对条件应激反应的回路的一部分。 BST 中的神经元对于充分表达催乳素对条件应激的反应非常重要。讨论了催乳素、肾素和 ACTH/皮质酮反应介导中的神经元回路和应激源特异性。
The contribution of the bed nucleus of the stria terminalis (BST) to the expression of stress-induced increases in ACTH/corticosterone, prolactin and renin secretion was assessed. Neurons in the lateral part of the BST were destroyed with bilateral injections of the cell-selective neurotoxin ibotenic acid (1.5 mug in 0.1 mul of solution per side). Two weeks later, the rats were stressed using an immobilization or conditioned stress paradigm. Rats with lesions in the lateral part of the BST showed attenuated ACTH and corticosterone responses to conditioned stress. Bilateral ablation of lateral BST significantly reduced the prolactin secretory response to conditioned stress. The same lesions had no effect upon plasma increases in renin that occur in response to conditioned stress. Also, destruction of neurons in the BST did not affect immobilization-induced increases in ACTH, corticosterone, prolactin or renin. Previous studies have demonstrated that ibotenic acid lesions in the central amygdala reduce corticosterone and renin response to conditioned stress. Thus, both the BST and central amygdala are important for the adrenocortical response to conditioned stress. Neurons in the central nucleus of the amygdala are part of the circuitry that mediates renin responses to conditioned stress. Neurons in the BST are important for the full expression of prolactin responses to conditioned stress. The neuronal circuitry and stressor specificity in the mediation of prolactin, renin and ACTH/corticosterone responses are discussed.