DIFFERENTIAL LIPID DEACYLATION DURING BRAIN ISCHEMIA IN A HOMEOTHERM AND A POIKILOTHERM - CONTENT AND COMPOSITION OF FREE FATTY-ACIDS AND TRIACYLGLYCEROLS
DIFFERENTIAL LIPID DEACYLATION DURING BRAIN ISCHEMIA IN A HOMEOTHERM AND A POIKILOTHERM - CONTENT AND COMPOSITION OF FREE FATTY-ACIDS AND TRIACYLGLYCEROLS
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DOI：
10.1016/0006-8993(75)90244-9
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发表时间：
1975-01-01
期刊：
影响因子：
2.9
通讯作者：
BAZAN, NG
中科院分区：
文献类型：
--
作者：
AVELDANO, MI;BAZAN, NG
比较小鼠和蟾蜍脑缺血时游离脂肪酸(FFA)和三酰甘油的含量和组成。小鼠脑FFA在断头后迅速增加，最大产生速率在第一分钟内达到最大。游离花生四烯酸和硬脂酸的增幅最大，其次是棕榈酸、油酸和二十二碳六烯酸。相比之下，只有在斩首几个小时后，蟾蜍脑的FFA才会有显著的变化。在缺血期间，三酰甘油在两栖动物的大脑中几乎保持不变，而在哺乳动物中，三酰甘油部分减少，在大约10分钟时达到几乎稳定的水平。这种甘油三酯的分解可能是一部分，但不能解释FFA中发生的所有变化。三酰甘油对FFA的贡献参差不齐。虽然中性甘油酯可能是游离棕榈酸的来源，但它们并不是花生四烯酸和硬脂酸增加的原因。提示FFA主要由极脂脱乙酰化引起，FFA变化缓慢可能与变温动物对缺氧的抵抗力较强有关。
The free fatty acid (FFA) and triacylglycerol content and composition are compared in the mouse and toad brain during ischemia. Mouse brain FFA are rapidly increased after decapitation, the maximal production rates being attained within the first minutes. Free arachidonic and stearic acids undergo the highest increases, followed by palmitic, oleic and docosahexaenoic. In contrast, toad brain FFA only change significantly several hours after decapitation. Triacylglycerols remain virtually unmodified in the amphibian brain during ischemia, whereas in the mammal they are partially decreased, reaching a nearly steady level at about 10 min. This triglyceride breakdown may represent a part, but cannot account for all the changes taking place in FFA. Uneven contributions to the FFA are shown for their counterparts in triacylglycerols. Although the neutral glycerides could be the source of free palmitic acid, they are not responsible for the increases in arachidonic and stearic acids. It is suggested that FFA mainly arise from polar lipid deacylation and a relationship is suggested between the slowness of FFA changes and the higher resistance of poikilotherms to oxygen deprivation.