Recent insights into noncanonical 5' capping and decapping of RNA.
Recent insights into noncanonical 5' capping and decapping of RNA.
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DOI：
10.1016/j.jbc.2022.102171
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发表时间：
2022-08
影响因子：
4.8
通讯作者：
Tong, Liang
中科院分区：
文献类型：
--
作者：
Doamekpor, Selom K.;Sharma, Sunny;Kiledjian, Megerditch;Tong, Liang
5′ N7-甲基鸟苷帽是真核细胞中mRNA和许多其他RNA的关键修饰。最近的研究发现了一种RNA 5′加帽质量监控机制，DXO/Rai 1脱帽酶去除不完整的帽，并使RNA降解，这一过程我们也称为“无帽衰变”。最近还发现，真核生物、细菌和古细菌中的RNA可以具有非典型帽（noncanonical cap，NCC），其主要来源于代谢物和辅因子，如NAD、FAD、脱磷酸辅酶A、UDP-葡萄糖、UDP-N-乙酰葡糖胺和二核苷酸多磷酸。这些NCC可以影响RNA稳定性，线粒体功能，并可能影响mRNA翻译。DXO/Rai 1酶和选定的Nuc（连接到X的核苷酸二磷酸）水解酶已显示通过其deNAD化、deFADding、deCoAping和相关活性从RNA中去除NCC，从而允许RNA的降解。在这篇综述中，我们总结了最近在RNA生物学这一令人兴奋的新领域的发现。
The 5′ N7-methylguanosine cap is a critical modification for mRNAs and many other RNAs in eukaryotic cells. Recent studies have uncovered an RNA 5′ capping quality surveillance mechanism, with DXO/Rai1 decapping enzymes removing incomplete caps and enabling the degradation of the RNAs, in a process we also refer to as “no-cap decay.” It has also been discovered recently that RNAs in eukaryotes, bacteria, and archaea can have noncanonical caps (NCCs), which are mostly derived from metabolites and cofactors such as NAD, FAD, dephospho-CoA, UDP-glucose, UDP-N-acetylglucosamine, and dinucleotide polyphosphates. These NCCs can affect RNA stability, mitochondrial functions, and possibly mRNA translation. The DXO/Rai1 enzymes and selected Nudix (nucleotide diphosphate linked to X) hydrolases have been shown to remove NCCs from RNAs through their deNADding, deFADding, deCoAping, and related activities, permitting the degradation of the RNAs. In this review, we summarize the recent discoveries made in this exciting new area of RNA biology.
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DOI：
10.2183/pjab.91.394
发表时间：
2015
期刊：
Proceedings of the Japan Academy. Series B, Physical and biological sciences
影响因子：
--
作者：
Furuichi Y
通讯作者：
Furuichi Y
影响因子：
14.9
作者：
Gao A;Vasilyev N;Luciano DJ;Levenson-Palmer R;Richards J;Marsiglia WM;Traaseth NJ;Belasco JG;Serganov A
通讯作者：
Serganov A
影响因子：
7.7
作者：
Bird, Jeremy G.;Basu, Urmimala;Nickels, Bryce E.
通讯作者：
Nickels, Bryce E.
影响因子：
4.1
作者：
Abdelraheim, SR;Spiller, DG;McLennan, AG
通讯作者：
McLennan, AG
影响因子：
14.9
作者：
Doamekpor, Selom K.;Grudzien-Nogalska, Ewa;Tong, Liang
通讯作者：
Tong, Liang