Expression of CD44 isoforms in infiltrating lobular carcinoma of the breast
Expression of CD44 isoforms in infiltrating lobular carcinoma of the breast
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DOI：
10.1023/a:1006417412046
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发表时间：
2001-01-01
影响因子：
3.8
通讯作者：
Nesland, JM
中科院分区：
文献类型：
--
作者：
Berner, HS;Nesland, JM
CD44的表达已被证明与一些恶性肿瘤的进展和预后有关。本研究的目的是评估CD44亚型在浸润性小叶癌中的表达，并分析其作为预后指标的潜力。采用免疫组化染色法检测39例肿瘤浸润细胞中膜质CD44s、v3、v5、v6、v7、v3-10的表达情况。除CD44v7抗体仅显示细胞质染色外，其余抗体均显示膜性和/或细胞质染色。CD44v3细胞质表达（P = 0.014）和CD44v3膜表达（P = 0.039）与肺泡癌、经典/肺泡癌和黏液/肺泡癌有显著相关性。此外，在肺泡癌、经典/肺泡癌和粘液/肺泡癌中，CD44v5细胞质染色与淋巴结阴性患者相关（P = 0.048），而膜性v5与淋巴结阳性患者相关（P = 0.048）。在经典、经典/小梁癌和小梁癌中，膜性CD44s的表达与淋巴结状态显著相关（P = 0.042）。
Expression of CD44 has been shown to correlate with the progression and prognosis of some malignant tumors. The aim of this study was to evaluate the expression of CD44 isoforms in infiltrating lobular carcinomas and analyse their potential as prognostic indicators. A panel of 39 tumors were examined for their expression of membranous and cytoplasmic CD44s, v3, v5, v6, v7 and v3-10 in the infiltrating cells, by immunohistochemical staining. The protein positive tumors showed membranous and/or cytoplasmic staining with all antibodies used except for CD44v7, which only displayed cytoplasmic staining. Cytoplasmic expression of CD44v3 (P = 0.014) and membranous expression of v6 (P = 0.039) were significantly associated with alveolar, classical/alveolar carcinomas and mucinous/alveolar carcinomas. Furthermore, in alveolar, classical/alveolar and mucinous/alveolar carcinomas, cytoplasmic staining of CD44v5 was correlated with lymph node negative patients (P = 0.048), whereas membranous v5 was correlated with lymph positive patients (P = 0.048). In classical, classical/trabecular and trabecular carcinomas expression of membranous CD44s was significantly correlated with lymph node status (P = 0.042).