High prevalence of parkinsonian disorders associated to manganese exposure in the vicinities of ferroalloy industries
High prevalence of parkinsonian disorders associated to manganese exposure in the vicinities of ferroalloy industries
复制标题
DOI：
10.1002/ajim.20494
复制
发表时间：
2007-11-01
影响因子：
3.5
通讯作者：
Alessio, Lorenzo
中科院分区：
文献类型：
--
作者：
Lucchini, Roberto G.;Albini, Elisa;Alessio, Lorenzo
目的评估与北方意大利布雷西亚省铁合金工业锰暴露有关的帕金森病的患病率。方法收集206个城市的沉降尘，测定锰浓度。帕金森病患者通过两个来源进行识别：（1）当地医院、专业神经科医生的临床登记，并免除处方费;（2）左旋多巴处方。标准化的患病率和原始和完整的贝叶斯平滑标准化发病率比（SMRs）计算为全省和每个municipal.Results锰浓度在沉降尘显着较高的周围和下风向的工业厂房。在903,997名居民中共发现2,677例帕金森病病例（粗患病率，2961 100,000; 95% CL。标准化患病率为407110000; 95%CI为393.87 - 420.12）。SMR显著更高（Kruskal-Wallis chi（2）1 df = 17.55，p <0.001），在37个城市的锰铁厂附近观察到（77，708名居民中324例;标准化患病率4921100，000; 95%CI：442.80 - 541.20），与全省其他169个市（826，289名居民中2，353例，标化患病率321/100，000; 95%CI 308.80 - 333.20）相比。行和贝叶斯SMR与锰的浓度在沉降dust.Conclusion研究结果表明，环境中暴露于锰与帕金森病的患病率增加。由于在工业所在地阿尔卑斯山前的一个封闭社区观察到最高的流行率，进一步的研究应解决遗传因素可能的相互作用。
Objective To assess the prevalence of Parkinsonian disturbances in relationship to environmental exposure to manganese due to ferroalloy industries in the province of Brescia, Northern Italy.Methods Manganese concentrations were measured in settled dust collected in each of the 206 municipalities. Parkinsonian patients were identified using two sources: (1) clinical registers from local hospitals, specialized neurologists, and exemption from prescription payment; (2) L-Dopa prescriptions. Standardized prevalence rates and raw and full Bayesian-smoothed standardized morbidity ratios (SMRs) were calculated for the entire province and for each municipality.Results Manganese concentrations in settled dust were significantly higher in the surroundings and downwind from the industrial plants. A total number of 2,677 Parkinsonian cases were identified among 903,997 residents (crude prevalence, 2961 100,000; 95% CL. 284.80-307.20; standardized prevalence, 4071100,000; 95% CI: 393.87-420.12). Significantly higher SMRs (Kruskal-Wallis chi(2) 1 df = 17.55, p < 0.001) were observed in 37 municipalities in the vicinities of ferromanganese plants (324 cases among 77,708 residents; standardized prevalence 4921100, 000; 95% CI: 442.80-541.20), compared to the other 169 municipalities of the province (2,353 cases among 826,289 residents, standardized prevalence 321/100,000; 95% CI 308.80-333.20). Row and Bayesian SMRs were associated with the concentrations of manganese in settled dust.Conclusion Study results suggest that environmental exposure to manganese is associated with an increased prevalence of Parkinsonian disturbances. Since the highest prevalence rates were observed in a closed community of the pre-Alps where the industries are located, further research should address a possible interactive role of genetic factors.