Genome Sequences of 28 Bordetella pertussis U.S. Outbreak Strains Dating from 2010 to 2012
Genome Sequences of 28 Bordetella pertussis U.S. Outbreak Strains Dating from 2010 to 2012
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DOI：
10.1128/genomea.01075-13
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发表时间：
2013-11-01
期刊：
影响因子：
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通讯作者：
Losada, Liliana
中科院分区：
文献类型：
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作者：
Harvill, Eric T.;Goodfield, Laura L.;Losada, Liliana
尽管有高效疫苗，但在高度接种疫苗的人群中，百日咳博德泰拉的发病率一直在迅速上升。最近的疫情引起了媒体的关注，引起了人们对出现毒性增强或逃避疫苗诱导免疫的危险新毒株的担忧。为了加速对这种重新出现的病原体的研究，我们对2010年至2012年爆发期间分离的28株百日咳菌株进行了基因组测序，使菌株和序列数据可用于科学界。
Despite the availability of highly effective vaccines, Bordetella pertussis incidence has been rapidly rising in highly vaccinated populations. Recent outbreaks have received media attention, feeding concerns about the emergence of dangerous new strains with increased virulence or that escape vaccine-induced immunity. To accelerate the study of this reemerging pathogen, we sequenced the genomes of 28 B. pertussis strains isolated during outbreaks from 2010 through 2012, making both strains and sequence data available to the scientific community.