The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs
The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs
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DOI：
10.1017/thg.2019.93
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发表时间：
2019-12-01
影响因子：
0.9
通讯作者：
Boomsma, Dorret I.
中科院分区：
文献类型：
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作者：
Ligthart, Lannie;van Beijsterveldt, Catharina E. M.;Boomsma, Dorret I.
荷兰双胞胎登记处（NTR）是一个全国性的登记处，双胞胎、多胞胎及其父母、兄弟姐妹、配偶和其他家庭成员参加。在这里，我们描述的NTR资源，从超过30年的数据收集创建;新开发的数据库系统的开发和维护，以及这些资源为未来的研究创造的可能性。自20世纪80年代初以来，NTR已经招募了大约12万对双胞胎和大约相同数量的亲属。大多数双胞胎家庭参加了调查研究，子样本参加了生物材料收集（例如，DNA）和专门的项目，例如，神经心理学，生物标志物和行为特征。NTR的招募是包容性的，没有任何入学限制。这些资源-纵向表型，扩展的谱系结构和多代基因分型-允许未来的双胞胎家庭的研究，将有助于基因发现，因果关系建模，遗传和文化遗传的研究。
The Netherlands Twin Register (NTR) is a national register in which twins, multiples and their parents, siblings, spouses and other family members participate. Here we describe the NTR resources that were created from more than 30 years of data collections; the development and maintenance of the newly developed database systems, and the possibilities these resources create for future research. Since the early 1980s, the NTR has enrolled around 120,000 twins and a roughly equal number of their relatives. The majority of twin families have participated in survey studies, and subsamples took part in biomaterial collection (e.g., DNA) and dedicated projects, for example, for neuropsychological, biomarker and behavioral traits. The recruitment into the NTR is all inclusive without any restrictions on enrollment. These resources - the longitudinal phenotyping, the extended pedigree structures and the multigeneration genotyping - allow for future twin-family research that will contribute to gene discovery, causality modeling, and studies of genetic and cultural inheritance.