DECREASED ROSETTE-FORMING LYMPHOCYTES IN MALNUTRITION AND INTRAUTERINE GROWTH RETARDATION
DECREASED ROSETTE-FORMING LYMPHOCYTES IN MALNUTRITION AND INTRAUTERINE GROWTH RETARDATION
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DOI：
10.1016/s0022-3476(74)80527-5
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发表时间：
1974-01-01
影响因子：
5.1
通讯作者：
STIEHM, ER
中科院分区：
文献类型：
--
作者：
FERGUSON, AC;LAWLOR, GJ;STIEHM, ER
外周血淋巴细胞与羊红细胞（胸腺依赖性淋巴细胞）自发形成玫瑰花的百分比作为两种形式营养不良患者细胞免疫的敏感指标进行了研究。与正常儿童（59.7%±1.4 SE）和白种人成人（64.5%±1.0 SE）相比，10例严重蛋白质-热量营养不良儿童的莲座形成细胞百分比和绝对数量（16.6%±2.7 SE）显著降低（p<0.001）。延迟性皮肤过敏也减轻，但总淋巴细胞计数和体外淋巴细胞对植物血凝素的反应正常。高蛋白、高热量饮食治疗导致延迟性皮肤过敏的恢复，并在1至3周内恢复到正常的莲座形成细胞数量。在10个胎龄较小的新生儿中，平均出生体重为1,660 gm，与体重适合妊娠的新生儿（65.1%±1.4 SE）平均出生体重为2,005 gm相比，玫瑰形成细胞的百分比中度减少（49.2%±2.0 SE） p<0.001，这一观察结果与先前关于这类婴儿脾脏和胸腺大小减少的研究一致。强调细胞免疫和营养不良的相互关系，因为这可能在宿主对感染和免疫的反应以及发育中的新生儿细胞免疫的持续缺陷中具有重要意义。
The percentage of peripheral blood lymphocytes which spontaneously form rosettes with sheep red blood cells (thymus-dependent lymphocytes) was studied as a sensitive measure of cellular immunity in patients with two forms of malnutrition. The percentage and absolute number of rosette-forming cells was markedly decreased in 10 children with severe protein-calorie malnutrition (16.6%±2.7 SE) p<0.001, compared to normal children (59.7%±1.4 SE) and Caucasian adults (64.5%±1.0 SE). Delayed cutaneous hypersensitivity was also diminished, but total lymphocyte counts and in vitro lymphocyte response to phytohemaglutinin were normal. Therapy with a high-protein, high-calorie diet resulted in recovery of delayed cutaneous hypersensitivity and return to normal numbers of rosette-forming cells within 1 to 3 weeks. The percentage of rosette-forming cells was moderately reduced (49.2%±2.0 SE) p<0.001, in 10 newborn infants who were small for gestational age, mean birth weight 1,660 gm, compared to those whose weights were appropriate for gestation (65.1%±1.4 SE), mean birth weight 2,005 gm, an observation in keeping with prior studies of diminished spleen and thymus size in such infants. The interrelation of cellular immunity and malnutrition is emphasized, since this may be of great importance in the host response to infection and immunization, and in persisting defects of cellular immunity in the developing newborn infant.