INDUCTION OF AUTOIMMUNE-THYROIDITIS IN CHICKENS BY DIETARY IODINE
INDUCTION OF AUTOIMMUNE-THYROIDITIS IN CHICKENS BY DIETARY IODINE
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DOI：
10.1126/science.4048936
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
SUNDICK, RS
中科院分区：
文献类型：
--
作者：
BAGCHI, N;BROWN, TR;SUNDICK, RS
临床研究表明，过量的膳食碘会促进自身免疫性甲状腺炎；然而，缺乏合适的动物模型阻碍了对这一现象的研究。在这项研究中，在已知易患自身免疫性甲状腺炎的鸡株的日粮中添加不同量的碘化钾。根据组织学和对三碘甲状腺原氨酸、甲状腺素和甲状腺球蛋白的自身抗体测定，在出生后的前10周服用碘会增加疾病的发病率。碘与自身免疫性甲状腺炎之间关系的进一步支持是由一项实验提供的，在该实验中，碘缺乏方案降低了高度敏感菌株中甲状腺自身抗体的发生率。这些结果表明，在美国，碘的过量摄入可能是自身免疫性甲状腺炎发病率增加的原因。
Clinical studies have suggested that excess dietary iodine promotes autoimmune thyroiditis; however, the lack of a suitable animal model has hampered investigation of the phenomenon. In this study, different amounts of potassium iodide were added to the diets of chicken strains known to be genetically susceptible to autoimmune thyroiditis. Administration of iodine during the first 10 weeks of life increased the incidence of the disease, as determined by histology and the measurement of autoantibodies to triiodothyronine, thyroxine, and thyroglobulin. Further support for the relation between iodine and autoimmune thyroiditis was provided by an experiment in which iodine-deficient regimens decreased the incidence of thyroid autoantibodies in a highly susceptible strain. These results suggest that excessive consumption of iodine in the United States may be responsible for the increased incidence of autoimmune thyroiditis.