Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery
Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery
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DOI：
10.3109/1061186x.2015.1058800
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发表时间：
2016-02-07
影响因子：
4.5
通讯作者：
Shi, Bizhi
中科院分区：
文献类型：
--
作者：
Fan, Mingliang;Liang, Xiaofei;Shi, Bizhi
特异性靶向肿瘤细胞以在肿瘤组织中实现更高的药物水平并克服副作用是癌症化疗的主要目标。在这项研究中，我们使用肿瘤靶向肽 GE11 缀合到阿霉素封装的磷脂胶束的表面。 GE11肽触发与表皮生长因子受体（EGFR）的特异性结合，导致体外细胞摄取和细胞毒性增强，并在体内肿瘤中高度积累。结果表明GE11共轭磷脂胶束在癌症治疗中应该具有潜在的应用。
Specific targeting of tumor cells to achieve higher drug levels in tumor tissue and to overcome side effects is the major goal in cancer chemotherapy. In this study, we used a tumor targeting peptide, GE11, to conjugate onto the surface of doxorubicin encapsulated phospholipid micelles. The GE11 peptide triggered specific binding to epidermal growth factor receptor (EGFR), leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation in the tumors in vivo. The results indicated that GE11 conjugated phospholipid micelles should have potential applications in cancer therapy.