Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art
Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art
复制标题
DOI：
10.1016/j.colsurfb.2016.11.036
复制
发表时间：
2017-02-01
影响因子：
5.8
通讯作者：
Katas, Haliza
中科院分区：
文献类型：
--
作者：
Hussain, Zahid;Thu, Hnin Ei;Katas, Haliza
伤口愈合是替换失活和受损细胞结构的多种多样且充满活力的过程，导致皮肤屏障功能的恢复、组织完整性的重建和内部稳态的维持。姜黄素（Curcumin，CUR）及其类似物具有显著的抗炎、抗感染、抗癌、免疫调节、抗氧化和伤口愈合等作用，已得到广泛的认可。然而，由于其固有的疏水性、水溶性差、生物利用度低、化学不稳定、代谢快和半衰期短，其药学意义受到限制。由于它们的药物局限性，近年来已经尝试了更新的策略，旨在减轻与姜黄素类化合物的有效递送相关的问题，并改善它们的伤口愈合潜力。这些先进的策略包括纳米囊泡、聚合物胶束、常规脂质体和透明体、纳米复合物水凝胶、电纺纳米纤维、纳米杂化支架、纳米缀合物、纳米结构脂质载体（NLC）、纳米乳液、纳米分散体和聚合物纳米颗粒（NP）。纳米包封CUR后实现的上级伤口愈合活性归因于其靶向特异性递送、在靶部位的更长保留、避免包封货物的过早降解以及先进递送系统相对于常规递送的治疗优效性。我们批判性地回顾了文献，并总结了令人信服的证据，这些证据探索了先进的给药系统在改善CUR及其类似物的伤口愈合活性方面的药学意义和治疗可行性。(C)2016爱思唯尔B.V.保留所有权利。
Wound healing is a multifarious and vibrant process of replacing devitalized and damaged cellular structures, leading to restoration of the skin's barrier function, re-establishment of tissue integrity, and maintenance of the internal homeostasis. Curcumin (CUR) and its analogs have gained widespread recognition due to their remarkable anti-inflammatory, anti-infective, anticancer, immunomodulatory, antioxidant, and wound healing activities. However, their pharmaceutical significance is limited due to inherent hydrophobic nature, poor water solubility, low bioavailability, chemical instability, rapid metabolism and short half-life. Owing to their pharmaceutical limitations, newer strategies have been attempted in recent years aiming to mitigate problems related to the effective delivery of curcum-anoids and to improve their wound healing potential. These advanced strategies include nanovesicles, polymeric micelles, conventional liposomes and hyalurosomes, nanocomposite hydrogels, electrospun nanofibers, nanohybrid scaffolds, nanoconjugates, nanostructured lipid carriers (NLCs), nanoemulsion, nanodispersion, and polymeric nanoparticles (NPs). The superior wound healing activities achieved after nanoencapsulation of the CUR are attributed to its target-specific delivery, longer retention at the target site, avoiding premature degradation of the encapsulated cargo and the therapeutic superiority of the advanced delivery systems over the conventional delivery. We have critically reviewed the literature and summarize the convincing evidence which explore the pharmaceutical significance and therapeutic feasibility of the advanced delivery systems in improving wound healing activities of the CUR and its analogs. (C) 2016 Elsevier B.V. All rights reserved.