Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications
Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications
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DOI：
10.1007/s00726-008-0190-y
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发表时间：
2009-04-01
期刊：
影响因子：
3.5
通讯作者：
Griffin, M.
中科院分区：
文献类型：
--
作者：
Collighan, R. J.;Griffin, M.
这篇综述总结了酶组织转氨酶（TG 2）在细胞外基质（ECM）中的功能，既可以通过其蛋白质交联活性作为基质稳定剂，也可以作为参与细胞存活的重要细胞粘附蛋白。细胞外TG2的贡献，重要的疾病，如癌症和纤维化的病理进行了讨论，鉴于TG2作为一个治疗靶点的潜在重要性。TG2的医疗应用进一步扩展，详细说明了使用转氨酶交联在开发新的生物相容性生物材料，用于软组织和硬组织修复。
This review summarises the functions of the enzyme tissue transglutaminase (TG2) in the extracellular matrix (ECM) both as a matrix stabiliser through its protein cross-linking activity and as an important cell adhesion protein involved in cell survival. The contribution of extracellular TG2 to the pathology of important diseases such as cancer and fibrosis are discussed with a view to the potential importance of TG2 as a therapeutic target. The medical applications of TG2 are further expanded by detailing the use of transglutaminase cross-linking in the development of novel biocompatible biomaterials for use in soft and hard tissue repair.