Hyperthermia for brain tumors: biophysical rationale.
Hyperthermia for brain tumors: biophysical rationale.
复制标题
脑肿瘤的热疗：生物物理学原理。
DOI：
10.1227/00006123-198109000-00021
复制
发表时间：
1981
期刊：
影响因子：
4.8
通讯作者：
G. Samaras
中科院分区：
文献类型：
--
作者：
M. Salcman;G. Samaras
热疗作为一种抗肿瘤药物具有很大的潜力，因为：(a)它对相对耐辐射的缺氧细胞和S期细胞有效；(b)与大多数化疗药物不同，它对血管化不良和代谢静止的组织有效；(c)作为物理制剂，其生物效应与其使用的持续时间和强度有关；(d)似乎没有累积毒性；(e)它在细胞水平上增强了化疗和电离辐射的作用。热疗治疗恶性脑肿瘤的使用受到相对狭窄的治疗指数和正常神经组织相当大的热敏性的限制。多形性胶质母细胞瘤，由于其低生长率和异质性细胞群，似乎是热疗的理想选择，作为综合治疗方案的一部分。局灶性热疗可以由许多能源产生，包括那些利用超声、微波和射频发生器。验证了微型微波辐射/传感器系统用于直接植入的临床安全性和可行性。与正常猫科动物的大脑相比，人类的恶性脑瘤不能有效地散热。
Hyperthermia has great potential as an antineoplastic agent because: (a) it is effective against relatively radioresistant hypoxic cells and cells in S phase; (b) unlike most chemotherapeutic agents, it is effective against poorly vascularized and metabolically quiescent tissues; (c) as a physical agent, its biological effect is related to the duration and intensity of its application; (d) it seems to have no cumulative toxicity; and (e) it potentiates the effects of both chemotherapy and ionizing radiation at the cellular level. The use of hyperthermia for malignant brain tumors is constrained by a relatively narrow therapeutic index and the considerable thermal sensitivity of normal neural tissue. Glioblastoma multiforme, by virtue of its low growth fraction and heterogeneous cell populations, seems to be an ideal candidate for hyperthermia administered as part of a combined modality treatment program. Focal hyperthermia can be produced by a number of energy sources, including those utilizing ultrasound, microwave, and radiofrequency generators. The clinical safety and feasibility of a miniature microwave radiator/sensor system for direct implantation have been demonstrated. In comparison to normal feline brain, malignant brain tumors in humans are unable to dissipate heat efficiently.