MicroRNAs AS BIOMARKERS OF RESILIENCE OR VULNERABILITY TO STRESS
MicroRNAs AS BIOMARKERS OF RESILIENCE OR VULNERABILITY TO STRESS
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DOI：
10.1016/j.neuroscience.2015.07.045
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发表时间：
2015-10-01
期刊：
影响因子：
3.3
通讯作者：
Bhatnagar, S.
中科院分区：
文献类型：
--
作者：
Chen, R. J.;Kelly, G.;Bhatnagar, S.
确定新的生物标志物的弹性或脆弱性的压力，可以提供有价值的信息，预防和治疗与压力有关的精神疾病。为了研究血液microRNA作为应激恢复力或脆弱性的生物标志物的效用，在大鼠慢性社交失败7天之前和之后评估了microRNA。此外，还评估了两个重要的压力调节大脑区域（内侧前额叶皮层（mPFC）和基底外侧杏仁核（BLA））的microRNA谱。表现出对随后的慢性应激易感性的大鼠表现出循环miR-24-2- 5 p、miR-27 a-3 p、miR-30 e-5 p、miR-3590- 3 p、miR-362- 3 p和miR-532- 5 p水平的降低。相比之下，与对照组相比，对压力具有弹性的大鼠显示出降低的miR-139- 5 p、miR-28- 3 p、miR-326- 3 p和miR-99 b-5 p水平。在mPFC中，与恢复性大鼠相比，脆弱性大鼠的miR-126 a-3 p和miR-708- 5 p水平更高。在BLA中，77种microRNA因压力而发生显著变化，但在有弹性和脆弱的动物之间没有显著差异。这些结果提供了原则证明，即循环microRNA的评估有助于识别易受未来压力影响的个体或对压力影响具有弹性的个体。此外，这些数据表明，在mPFC而不是在BLA中的microRNA是对压力的弹性/脆弱性的调节器。(C)2015年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Identifying novel biomarkers of resilience or vulnerability to stress could provide valuable information for the prevention and treatment of stress-related psychiatric disorders. To investigate the utility of blood microRNAs as biomarkers of resilience or vulnerability to stress, microRNAs were assessed before and after 7 days of chronic social defeat in rats. Additionally, microRNA profiles of two important stress-regulatory brain regions, the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA), were assessed. Rats that displayed vulnerability to subsequent chronic stress exhibited reductions in circulating miR-24-2-5p, miR-27a-3p, miR-30e-5p, miR-3590-3p, miR-362-3p, and miR-532-5p levels. In contrast, rats that became resilient to stress displayed reduced levels of miR-139-5p, miR-28-3p, miR-326-3p, and miR-99b-5p compared to controls. In the mPFC, miR-126a-3p and miR-708-5p levels were higher in vulnerability compared to resilient rats. In the BLA, 77 microRNAs were significantly altered by stress but none were significantly different between resilient and vulnerable animals. These results provide proof-of-principle that assessment of circulating microRNAs is useful in identifying individuals who are vulnerable to the effects of future stress or individuals who have become resilient to the effects of stress. Furthermore, these data suggest that microRNAs in the mPFC but not in the BLA are regulators of resilience/vulnerability to stress. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.