Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe
Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe
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DOI：
10.1007/s12272-001-1172-y
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发表时间：
2008-04-01
影响因子：
6.7
通讯作者：
Kim, Dae Keun
中科院分区：
文献类型：
--
作者：
Kim, Ju Sin;Lee, Sa Im;Kim, Dae Keun
Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53(-/-), c-myc, K-ras) and C2 (genotype: p53(-/-), c-myc, Akt), with ED50 values of 0.58 mu M (C1) and 10.7 mu M (C2).
