Normal fMRI brain activation patterns in children performing a verb generation task
Normal fMRI brain activation patterns in children performing a verb generation task
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DOI：
10.1006/nimg.2001.0875
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发表时间：
2001-10-01
期刊：
影响因子：
5.7
通讯作者：
Ball, WS
中科院分区：
文献类型：
--
作者：
Holland, SK;Plante, E;Ball, WS
尽管人们对成人大脑与语言的关系了解很多，但对于这些功能在发育期间如何表现却知之甚少。我们报告了 17 名年龄在 7-18 岁的正常儿童的结果，他们在 3 特斯拉的功能磁共振成像过程中成功完成了单词流利范例。激活区域复制了成年受试者报告的激活区域。然而，在儿童中发现激活的半球偏侧化与年龄之间存在统计学上显着的关联。具体来说，尽管所有年龄段的大多数受试者在这项任务中都表现出左半球优势，但侧化程度随着年龄的增长而增加。这项研究表明，MRI 可以揭示与语义语言功能相关的大脑激活模式的发育变化。 (C) 2001 年学术出版社。
Although much is known concerning brain-language relations in adults, little is known about how these functions might be represented during the developmental period. We report results from 17 normal children, ages 7-18 years, who have successfully completed a word fluency paradigm during functional magnetic resonance imaging at 3 Tesla. Regions of activation replicate those reported for adult subjects. However, a statistically significant association between hemispheric lateralization of activation and age was found in the children. Specifically, although most subjects at all ages showed left hemisphere dominance for this task, the degree of lateralization increased with age. This study demonstrates that MRI can reveal developmental shifts in the pattern of brain activation associated with semantic language function. (C) 2001 Academic Press.