Fruit and Vegetable Intake in Relation to Risk of Breast Cancer in the Black Women's Health Study
Fruit and Vegetable Intake in Relation to Risk of Breast Cancer in the Black Women's Health Study
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DOI：
10.1093/aje/kwq293
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发表时间：
2010-12-11
影响因子：
5
通讯作者：
Rosenberg, Lynn
中科院分区：
文献类型：
--
作者：
Boggs, Deborah A.;Palmer, Julie R.;Rosenberg, Lynn
作者在1995年参加黑人妇女健康研究的51,928名年龄在21-69岁之间的妇女中前瞻性地检查了水果和蔬菜摄入量与乳腺癌风险的关系。饮食摄入量通过使用经验证的食物频率问卷进行评估。考克斯比例风险模型用于估计发病率比和95%置信区间，调整乳腺癌的危险因素。在12年的随访中，有1，268例乳腺癌病例。总水果、总蔬菜以及水果和蔬菜的总摄入量与乳腺癌的总体风险没有显著相关。然而，总蔬菜消费量与雌激素受体阴性/孕激素受体阴性乳腺癌风险降低相关（发病率比= 0.57，95%置信区间：0.38，0.85，>= 2份/天相对于< 4份/周; P（趋势）= 0.02）。此外，有证据表明十字花科蔬菜摄入量（P（趋势）= 0.06）和胡萝卜摄入量（P（趋势）= 0.02）与乳腺癌风险呈负相关。研究结果表明，经常食用蔬菜与雌激素受体阴性/孕激素受体阴性乳腺癌的风险呈负相关，特定蔬菜可能与整体乳腺癌风险降低有关。
The authors prospectively examined the relation of fruit and vegetable intake to breast cancer risk among 51,928 women aged 21-69 years at enrollment in 1995 in the Black Women's Health Study. Dietary intake was assessed by using a validated food frequency questionnaire. Cox proportional hazards models were used to estimate incidence rate ratios and 95% confidence intervals, adjusted for breast cancer risk factors. During 12 years of follow-up, there were 1,268 incident cases of breast cancer. Total fruit, total vegetable, and total fruit and vegetable intakes were not significantly associated with overall risk of breast cancer. However, total vegetable consumption was associated with a decreased risk of estrogen receptor-negative/progesterone receptor-negative breast cancer (incidence rate ratio = 0.57, 95% confidence interval: 0.38, 0.85, for >= 2 servings/day relative to < 4/week; P(trend) = 0.02). In addition, there was some evidence of inverse associations with breast cancer risk overall for cruciferous vegetable intake (P(trend) = 0.06) and for carrot intake (P(trend) = 0.02). Study findings suggest that frequent consumption of vegetables is inversely associated with risk of estrogen receptor-negative/progesterone receptor-negative breast cancer, and that specific vegetables may be associated with a decreased risk of breast cancer overall.