Epidemiological Findings and Laboratory Evaluation of Sporotrichosis: A Description of 103 Cases in Cats and Dogs in Southern Brazil
Epidemiological Findings and Laboratory Evaluation of Sporotrichosis: A Description of 103 Cases in Cats and Dogs in Southern Brazil
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DOI：
10.1007/s11046-011-9509-4
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发表时间：
2012-04-01
期刊：
影响因子：
5.5
通讯作者：
Araujo Meireles, Mario Carlos
中科院分区：
文献类型：
--
作者：
Madrid, Isabel Martins;Mattei, Antonella Souza;Araujo Meireles, Mario Carlos
孢子丝菌病是一种皮下真菌病，主要影响小动物，被认为是一种重要的公共卫生疾病。本文描述了在巴西南部10年期间诊断的103例孢子虫病临床病例的流行病学和实验室特征。来自南里奥格兰德州8个城市的92只猫和11只狗特别发展了该疾病的播散性皮肤和固定性皮肤形式。在约57%的动物中发现呼吸道体征，如打喷嚏、浆液性鼻涕和呼吸困难。申克孢子丝菌在睾丸、口腔和结膜中的检出率分别为46.6%、45.2%和38.1%。一个分化的组织学模式之间的固定的皮肤和播散性皮肤（DC）的疾病的表现，组织良好的肉芽肿结节状分布和各种真菌结构的DC形式在猫中盛行。S.用Fontana-Masson法检测申克氏细胞阳性率为45.4%。该研究表明，南里奥格兰德州是一个地方性孢子虫病地区，并表明该疾病的感染和传播可能涉及其他途径。此外，它强调了实验室检查对真菌病确认的重要性，特别是在不存在皮肤病变的情况下出现临床表现的犬中。
Sporotrichosis is a subcutaneous mycosis, which affects mainly small animals, and is considered an important public health disease. This paper describes the epidemiological and laboratory characteristics of 103 clinical cases of sporotrichosis diagnosed over a 10-year period in southern Brazil. The 92 cats and 11 dogs from eight municipalities in Rio Grande do Sul State developed especially the disseminated cutaneous and fixed cutaneous forms of the disease. Respiratory signs such as sneezing, serous nasal discharge and dyspnea were found in about 57% of the animals. The detection of Sporothrix schenckii in different clinical samples showed highest isolation in testicles (46.6%), oral cavity (45.2%) and conjunctival mucosa (38.1%). A differentiated histological pattern was found between the fixed cutaneous and disseminated cutaneous (DC) manifestations of the disease; well-organized granulomas of nodular distribution and various fungal structures prevailed in the DC form in cats. Melanin detection in S. schenckii cells by the Fontana-Masson technique was positive in 45.4% of the samples. The study revealed that the State of Rio Grande do Sul is an endemic sporotrichosis area and demonstrated the possibility of involvement of other pathways in the infection and spread of the disease. In addition, it emphasized the importance of laboratory tests for mycosis confirmation, especially in dogs that develop clinical manifestations without the presence of cutaneous lesions.