Prognostic significance of dysadherin and E-cadherin expression in patients with head and neck cancer treated by radiation therapy.
Prognostic significance of dysadherin and E-cadherin expression in patients with head and neck cancer treated by radiation therapy.
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发表时间：
2008-11
影响因子：
2
通讯作者：
H. Muramatsu;T. Akimoto;K. Maebayashi;M. Kita;N. Mitsuhashi
中科院分区：
文献类型：
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作者：
H. Muramatsu;T. Akimoto;K. Maebayashi;M. Kita;N. Mitsuhashi
背景：本研究的目的是评估粘附素和E-钙粘附素的表达对头颈癌患者的临床结果的影响，包括治疗结果和复发模式。患者与方法48例接受放射治疗的头颈部肿瘤标本，采用免疫组织化学方法检测肿瘤组织中粘附素和E-钙粘附素的表达。按E-钙粘附素和粘附素表达阳性的癌细胞所占面积百分比进行分级：0级，<10%；1级，10~50%；2级，>50%。分析E-钙粘附素和粘附素表达与临床疗效(包括治疗结果和复发方式)的相关性。结果粘附素表达不良0级或1级患者的完全缓解率(CR)为70%，2级患者CR率为38%，差异有统计学意义(P<；0.05)。Dys-ECAD值为1或2的患者，其淋巴结和/或远处转移率(55%)显著高于Dys-ECAD值为1的患者(22%)(p<；0.05)。结论Dys粘附素和E-钙粘附素的表达可作为头颈癌放射治疗患者预后的有用指标。
BACKGROUND The aim of this study was to evaluate the impact of dysadherin and E-cadherin expression on the clinical outcomes, including the treatment outcomes and recurrence pattern, in patients with head and neck cancer. PATIENTS AND METHODS Tumor specimens were obtained from 48 head and neck cancer patients who were treated by radiation therapy and the specimens were immunohistochemically stained for dysadherin and E-cadherin. The expressions were graded according to the percentage area occupied by cancer cells showing positive staining for E-cadherin and dysadherin as follows: grade 0, less than 10%; grade 1, 10-50%; grade 2, more than 50%. The correlations between the expression of E-cadherin and dysadherin and the clinical outcomes, including the treatment outcomes and recurrence pattern, were analyzed. RESULTS The complete response (CR) rate in the patients with a dysadherin expression grade of 0 or 1 was 70% and that in the patients with dysadherin expression grade of 2 was 38%; the difference was significant (p < 0.05). Regarding the pattern of recurrence, the expression grade of dysadherin or E-cadherin alone was not correlated with the recurrence pattern; however, patients with a difference in the expression grade between dysadherin and E-cadherin (Dys-Ecad value) of 1 or 2 showed a significantly higher rate of lymph node and/or distant metastasis (55%) as compared with those with a Dys-Ecad value of < 1 (22%) (p < 0.05). CONCLUSION Dysadherin and E-cadherin expression might serve as useful prognostic factors in patients with head and neck cancer treated by definitive radiation therapy.