B-vitamins reduce plasma levels of beta amyloid
B-vitamins reduce plasma levels of beta amyloid
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DOI：
10.1016/j.neurobiolaging.2006.10.007
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发表时间：
2008-02-01
影响因子：
4.2
通讯作者：
Almeida, Osvaldo P.
中科院分区：
文献类型：
--
作者：
Flicker, Leon;Martins, Ralph N.;Almeida, Osvaldo P.
血浆同型半胱氨酸（tHcy）升高是阿尔茨海默病（AD）的危险因素，因此B族维生素可能在预防AD中发挥作用。本研究的目的是确定降低tHcy的维生素是否会降低A-β蛋白1-40（A β 40）的循环水平。我们将299名老年男性随机分配接受2毫克叶酸、25毫克B6和400微克B 12或安慰剂治疗。治疗2年后，平均（S.E.）维生素组A β 40升高7.0pg/ml（8.4）（4.9%），安慰剂组升高26.8pg/ml（7.7）（18.5%）。我们的结论是，B族维生素可能会降低血浆中A β 40的水平，并在预防AD的作用。(C)2006年爱思唯尔公司All rights reserved.
Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1-40 (A beta 40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 mu g of B 12, or placebo. After 2 years of treatment the mean (S.E.) increase of A beta 40 was 7.0pg/ml (8.4) in the vitamin group (4.9%), and 26.8pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of A beta 40 and have a role in the prevention of AD. (C) 2006 Elsevier Inc. All rights reserved.